Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity
DC CAFC
First Claim
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1. A method for enhancing physical performance of a mammal prior to said physical performance, said method comprising:
- administering to said mammal prior to said physical performance as the active ingredient an amino acid composition consisting of at least one amino acid selected the group consisting of arginine and lysine of at least about 60 mg/kg/day within 24 h of said physical performance.
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Abstract
NO precursors are administered at elevated levels in addition to the diet of the individual to enhance exercise performance. Particularly, L-arginine and L-lysine by enhancing endothelial NO production can provide for greater aerobic capacity and improved exercise performance.
154 Citations
15 Claims
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1. A method for enhancing physical performance of a mammal prior to said physical performance, said method comprising:
administering to said mammal prior to said physical performance as the active ingredient an amino acid composition consisting of at least one amino acid selected the group consisting of arginine and lysine of at least about 60 mg/kg/day within 24 h of said physical performance. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for enhancing human physical performance prior to said physical performance, said method comprising:
administering to said human within 6 h prior to said physical performance as the active ingredient an amino acid composition consisting of at least one amino acid selected from the group consisting of arginine and lysine of at least about 2 g per day in combination with an agent enhancing ENDO synthesis, as a health bar, grain or drink. - View Dependent Claims (8, 9, 10)
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11. A method for enhancing physical performance of a mammal prior to physical exertion, said method comprising:
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at least about 3 days prior to said physical exertion, administering to said mammal an NOS inhibitor for inhibiting NOS; and within about 3 days prior to said physical exertion, discontinuing the NOS inhibitor, and administering to said mammal an agent enhancing EDNO synthesis.
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- 12. A method enhancing human physical performance prior to said physical performance, said method comprising:
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13. administering to said human prior to said physical performance as the active ingredient an amino acid composition consisting of at least one amino acid selected from the group consisting of arginine and lysine of at least about 2 g per day within 24 h of said physical performance.
Specification
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Litigation Data
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Current AssigneeBoard of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
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Original AssigneeBoard of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
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InventorsCooke, John P., Maxwell, Andrew J.
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Primary Examiner(s)MOEZIE, MINNA FAY
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Application NumberUS09/103,340Time in Patent Office812 DaysField of Search514/249, 514/458, 514/474, 514/556, 514/564, 514/565, 514/665, 514/625, 514/763, 424/702US Class Current514/249CPC Class CodesA61K 2300/00 Mixtures or combinations of...A61K 31/195 having an amino groupA61K 31/198 Alpha-amino acids, e.g. ala...A61K 31/505 Pyrimidines; Hydrogenated p...
