Amino-ketone solid support templates
First Claim
1. A solid phase reaction component for the production of an amino containing chemical compound in a reaction media, said solid phase reaction component comprising an amino-ketone core compound linked to a polymer substrate, said reaction component being insoluble in said reaction media.
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Abstract
A solid support template for solid phase synthesis of amino group containing compounds is provided that comprises amino-ketone core compounds of the general formula:
A-L-NH(CR.sub.1 R.sub.2).sub.n COR.sub.3
linked to appropriate insoluble substrates to create solid support templates having the general formula:
Polymer-X-L-NH(CR.sub.1 R.sub.2).sub.n COR.sub.3
where L is a multifunctional monomer carrying a first functional group that forms a covalent bond with X and a second functional group comprising an amine and L, R1, R2 and R3 are selected from the group consisting of alkyl, alkyl-aryl, alkenyl, alkenyl-aryl groups having up to 6 carbon atoms and substituted forms thereof. The amino-ketone templates are useful for the solid phase synthesis of compounds such as the imidazoles, benzodiazepines, pyrazines, and steroid mimics.
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Citations
29 Claims
- 1. A solid phase reaction component for the production of an amino containing chemical compound in a reaction media, said solid phase reaction component comprising an amino-ketone core compound linked to a polymer substrate, said reaction component being insoluble in said reaction media.
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14. A method for the solid phase production of an amino containing compound in a reaction media comprising the steps of:
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a. forming a solid phase support template comprising an amino-ketone core compound linked to a polymer substrate, said reaction template being insoluble in said reaction media and having the formula
space="preserve" listing-type="equation">Polymer-X-L-NH(CR.sub.1 R.sub.2).sub.n COR.sub.3wherein;
n=1 or 2;
X is a moiety that forms a covalent bond to join said polymer and said amino-ketone core compound;
L is a multifunctional monomer carrying a first functional group that forms a covalent bond with X and a second functional group comprising an amino group and L, R1, R2 and R3 are selected from the group consisting of alkyl, alkyl-aryl, alkenyl, alkenyl-aryl groups having up to 6 carbon atoms and substituted forms thereof;b. reacting said solid phase support template in said reaction media to form a reaction product comprising said desired amino containing compound linked to said resin; c. cleaving said reaction product; and d. separating said desired amino containing compound from said reaction media. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification