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Pyrimidines linked to a quencher

  • US 6,117,986 A
  • Filed: 06/10/1998
  • Issued: 09/12/2000
  • Est. Priority Date: 06/10/1998
  • Status: Expired due to Term
First Claim
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1. A derivatized pyrimidine compound having the structure ##STR10## wherein Pyr represents a pyrimidine substituted at the 5 position with a linker L and said linker comprising at least three carbon atoms and is linking the pyrimidine with the quencher;

  • wherein Q is a quencher andwhenever x is an activated phosphorus group capable of intermolecular bond formation with a 3'"'"' hydroxyl of another nucleotide, then y is a protected hydroxyl group and z is --H, --F, --OCH3, --O-allyl or a protected hydroxyl or amine group andwhenever y is an activated phosphorus group capable of intermolecular bond formation with a 5'"'"' hydroxyl of another nucleotide then x is a protected hydroxyl group and z is --H, --F, --OCH3, --O-allyl or a protected hydroxyl or amine group.

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