Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces
First Claim
1. An implantable monitoring system comprising:
- at least one enzymatic sensor assembly;
an outer membrane surrounding the enzymatic sensor assembly, the outer membrane having at least one window therein; and
a window cover associated with the outer membrane such that the window is covered thereby.
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Accused Products
Abstract
An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
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Citations
29 Claims
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1. An implantable monitoring system comprising:
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at least one enzymatic sensor assembly; an outer membrane surrounding the enzymatic sensor assembly, the outer membrane having at least one window therein; and a window cover associated with the outer membrane such that the window is covered thereby. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An implantable monitoring system comprising:
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at least one sensor assembly; an outer membrane surrounding the sensor assembly, the outer membrane having at least one window therein, a window cover associated with the outer membrane such that the window is covered thereby; and a coating on the exterior surface of the outer membrane, which coating resists blood coagulation and protein binding to the exterior surface of the outer membrane; wherein the coating further comprises at least two active components; and wherein at least one of the components is selected from the group consisting of heparin and polyethylene glycol. - View Dependent Claims (10, 11, 12)
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13. An implantable monitoring system comprising:
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at least one sensor assembly; an outer membrane surrounding the sensor assembly, the outer membrane having a break therein over at least a portion of the sensor assembly wherein the break forms a window extending completely through the outer membrane; a window cover located within the window; wherein the window cover comprises 2-hydroxyethyl methacrylate (HEMA); and
methacrylic acid (MA); anda coating on the exterior surface of at least one of the outer membrane and window cover, which coating comprises polyethylene glycol and heparin. - View Dependent Claims (14, 15)
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16. An implantable monitoring system comprising:
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at least one sensor assembly; an outer membrane surrounding the sensor assembly, the outer membrane having at least one break therein over a selected portion of the sensor assembly; wherein the break forms a window through the outer membrane; and wherein the outer membrane is permeable to a first selected substance but is not substantially permeable to a second selected substance; a window cover comprising a material permeable to both the first selected substance and the second selected substance; wherein the window cover material is located over only a portion of the sensor assembly; and wherein the surrounded sensor assembly a capable of being implanted in a living body. - View Dependent Claims (17, 18, 19)
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20. An implantable monitoring system comprising:
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at least one sensor assembly; an outer membrane surrounding the sensor assembly; and a coating that resists blood coagulation located on an exterior surface of the outer membrane; wherein the coating comprises a substance that is, in part, covalently bound to the outer membrane and, in part, ionically bound to the outer membrane; and wherein the surrounded sensor assembly is capable of being implanted in a living body. - View Dependent Claims (21, 22, 23, 24, 25)
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26. An implantable monitoring system for sensing glucose comprising:
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at least one sensor assembly; an outer membrane surrounding the sensor assembly, the outer membrane having at least one break located over a selected portion of the sensor assembly; wherein the break extends completely through the outer membrane and forms a window through the outer membrane, and wherein the outer membrane is permeable to a first selected substance but is not substantially permeable to glucose; and a window cover at least partially filling the window, wherein the window cover is permeable to both the first substance and to glucose; and wherein the surrounded sensor assembly is capable of being implanted in a body of a patient. - View Dependent Claims (27, 28, 29)
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Specification