Cardiac pacemaker upper rate limit control

• US 6,119,040 A
• Filed: 06/29/1998
• Issued: 09/12/2000
• Est. Priority Date: 06/29/1998
• Status: Expired due to Term

• Current Assignee: Dr. Raul Chirife
• Original Assignee: Dr. Raul Chirife
• Inventors: Chirife, Raul
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US09/106,674
• Time in Patent Office: 806 Days
• Field of Search: 607/18
• US Class Current: 607/18
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

Method and apparatus for automatically setting a variable upper rate limit for the pacing pulse signal provided by a rate adaptive implantable pacemaker which relies on a non-physiological sensor to determine the pacing needs of the patient. A physiological parameter of the patient'"'"'s condition is sensed and used to determine an upper limit for the pacing rate otherwise called for based on the reading of the non-physiological sensor. In a disclosed embodiment, the ventricular preejection period is monitored as the physiological parameter, and the rate of change of this parameter is utilized to set the upper limit of the pacing pulse rate.

Claims

1. A rate adaptive cardiac pacemaker, implantable in a patient, comprising:

apparatus comprising a first sensor operative to sense a non-physiological parameter of the condition of the patient and to provide a first electric signal representative of the non-physiological parameter;

apparatus comprising a second sensor operative to sense a physiological parameter of the condition of the patient and to provide a second electric signal representative of the physiological parameter;

a pacing pulse signal generator;

electrodes that receive the pacing pulse signals from the pulse generator and apply them to the heart of the patient for stimulating the heart;

short term averaging circuitry that receives physiological signals representative of successive measures of physiological signals and averages them over a short term;

long term averaging circuitry that receives physiological signals representative of successive measures of physiological signals and averages them over a term longer than said short term; and

calculating circuitry that determines the ratio of the average of the measures of physiological signals over the short term to the average of the measures of physiological signals over the long term to produce a result that represents the rate of change of the physiological signals;

apparatus comprising control circuitry that produces command signals that command the pulse generator to provide pacing pulse signals, that determines the rate of the pacing pulse signals so commanded based on information received from the first electric sensor signal, and that so determines the rate of the pacing pulse signals subject to upper rate limits selected based on information received from the calculating circuitry.

2. A pacemaker according to claim 1, wherein said short term averaging circuitry receives signals representative of the lengths of successive preejection periods and averages them over a short term;

long term averaging circuitry that receives signals representative of the lengths of successive preejection periods and averages them over a term longer than said short term; and

calculating circuitry that determines the ratio of the average of the preejection periods over the short term to the average of the preejection periods over the long term to produce a result that represents the rate of change of the preejection period.

3. A pacemaker according to claim 2 wherein said calculating circuitry determines upper rate limits for pacing pulse signals based on the rate of change of the preejection period.

4. A pacemaker according to claim 3 wherein said circuitry compares information from the first sensor electric signal with the determined upper rate limit for a pacing pulse signal and sets the rate for pacing pulse signal based on the comparison.

5. A body implantable rate adaptable cardiac pacemaker comprising:

a demand-type artificial heart stimulus pulse generator and electrodes for applying generated artificial stimulus signals to the heart for stimulating the heart to beat on demand;

an electrocardiograph device operative to detect occurrence on the heart of natural QRS heart beat stimulus signals and artificial stimulus signals during each heart cycle, detection of either of the stimulus signals indicating the start of the heart preejection period (PEP),

a programable controller having an input for detected stimulus signals,

a device for detecting substantially the beginning of ejection of blood from a ventricle of the heart during each heart cycle and for producing a corresponding signal that indicates the end of the PEP,

a PEP duration measuring circuit having an input for a signal representing the start of each PEP and an input for the signal that indicates the end of the PEP and the circuit outputs duration signals representative of the durations of successive PEPs,

a first memory device operative to store and determine the average of the PEP duration signals over one interval and a second memory device operative to store PEP duration signals and determine the average of the PEP signals over an interval that is longer than the one interval, said controller operating to periodically take the ratio of the average of the one and the longer intervals to produce a signal representative of the rate of change of the PEP,

the controller operating to set the upper limit of the artificial stimulus pulse generator stimulus rate to change inversely with the rate of change of the PEP,

a motion sensor operating to sense motion of the body in which the pacemaker is implanted and to supply a signal indicative of motion being sensed to the controller, the controller responding by setting the upper limit of the artificial stimulus pulse if motion is sensed concurrently with a decrease in the PEP.

6. A pacemaker according to claim 5 wherein said PEP duration measuring circuit comprises circuitry for sensing the ventricular impedance of the heart and for developing a signal corresponding to substantially the highest impedance occurring in each heart cycle, said signal being indicative of the end of the PEP.

7. A pacemaker according to claim 6 wherein said circuitry for sensing the ventricular impedance includes:

an oscillator having an output coupled to the electrodes for applying a carrier frequency signal to the heart for impedance variations to modulate the carrier, and

circuitry for demodulating the carrier to yield a signal representative of the impedance level of the heart.

8. A pacemaker according to claim 6 wherein said motion sensor is a piezoelectric device.

9. A pacemaker according to claim 5 wherein said motion sensor is comprised of an accelerometer.

10. A pacemaker according to claim 5 including circuitry operative to determine the rate of change of the PEP in a succession of heart cycles, said circuitry comprising

a short interval averaging circuit having an input for signals representative of the lengths of successive PEPs over a predetermined interval and averages them,

a long interval averaging circuit having an input for signals representative of the lengths of successive PEPs over an interval that is longer than said predetermined interval and averages them, and

the controller determining the ratio of the averages of the successive PEPs to produce a resulting signal that represents the rate of change of the PEPs.

11. A pacemaker according to claim 10 wherein said resulting signal is coupled to the heart stimulus pulse generator for controlling the upper pulse rate limit of the generator.