Method and device for arterial blood pressure measurement
First Claim
1. A method for measuring arterial diastolic blood pressure in a subject, the method comprising:
- (a) generating first and second signals indicative, respectively, of cardiac induced pulsatile variations in tissue blood volume in a first region and a second region of the subject'"'"'s body;
(b) processing said first and second signals to derive values of a delay between pulses in said first signal and corresponding pulses in second signal;
(c) evaluating a baseline value of said delay;
(d) applying a variable pressure to a third region of the subject'"'"'s body so as to affect blood flow through at least one artery in said third region, said variable pressure being varied as a function of time, said first, said second and said third regions being chosen such that said delay varies as a function of said variable pressure; and
(e) identifying a value of said variable pressure corresponding substantially to a predefined non-zero value of said delay measured relative to said baseline value.
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Abstract
A method of measurement of arterial diastolic blood pressure includes generating first and second signals indicative, respectively, of cardiac induced pulsatile variations in tissue blood volume in a first region and a second region of the subject'"'"'s body. These signals are then processed to derive values of a delay between pulses in the first signal and corresponding pulses in second signal. A baseline value of the delay is evaluated, preferably in the absence of externally applied pressure. A variable pressure is applied to a third region of the subject'"'"'s body so as to affect blood flow through at least one artery in the third region, the variable pressure being varied as a function of time. The first, second and third regions of the subject'"'"'s body are chosen such that the delay varies as a function of the variable pressure. The diastolic pressure is then identified as a value of the variable pressure corresponding to a predefined non-zero value of the delay measured relative to the baseline value.
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Citations
17 Claims
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1. A method for measuring arterial diastolic blood pressure in a subject, the method comprising:
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(a) generating first and second signals indicative, respectively, of cardiac induced pulsatile variations in tissue blood volume in a first region and a second region of the subject'"'"'s body; (b) processing said first and second signals to derive values of a delay between pulses in said first signal and corresponding pulses in second signal; (c) evaluating a baseline value of said delay; (d) applying a variable pressure to a third region of the subject'"'"'s body so as to affect blood flow through at least one artery in said third region, said variable pressure being varied as a function of time, said first, said second and said third regions being chosen such that said delay varies as a function of said variable pressure; and (e) identifying a value of said variable pressure corresponding substantially to a predefined non-zero value of said delay measured relative to said baseline value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A device for measuring arterial diastolic blood pressure in a subject, the device comprising:
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(a) a pressure cuff applicable to a first region of the subject'"'"'s body so as to affect blood flow through at least one artery in said first region; (b) a pressure controller operatively connected to said pressure cuff so as to vary a current pressure of said pressure cuff; (c) first and second plethysmography sensors for application to a second region and a third region of the subject'"'"'s body, said first and second plethysmography sensors being configured to produce first and second signals, respectively, indicative of pulsatile variations in tissue blood volume in said second and third regions, respectively; and (d) a processor associated with said pressure controller and with said first and second plethysmography sensors, said processor being configured to; (i) process said first and second signals to derive values of a delay between pulses in said first signal and corresponding pulses in second signal, (ii) evaluate a baseline value of said delay corresponding to a current pressure substantially equal to ambient pressure, and (iii) identify as the diastolic pressure a value of said variable pressure corresponding substantially to a predefined non-zero value of said delay measured relative to said baseline value.
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15. A method for measuring arterial diastolic blood pressure in a subject, the method comprising:
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(a) generating first and second signals indicative, respectively, of cardiac induced pulsatile variations in tissue blood volume in a first region and a second region of the subject'"'"'s body; (b) processing said first and second signals to derive values of a measure of correlation between pulses in said first signal and corresponding pulses in second signal; (c) applying a variable pressure to a third region of the subject'"'"'s body so as to affect blood flow through at least one artery in said third region, said variable pressure being varied as a function of time, said first, said second and said third regions being chosen such that said measure of correlation varies as a function of said variable pressure; and (d) identifying a value of said variable pressure corresponding to a value of said measure of correlation substantially equal to a predefined value. - View Dependent Claims (16, 17)
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Specification