Radio prosthesis

• US 6,120,540 A
• Filed: 01/21/1999
• Issued: 09/19/2000
• Est. Priority Date: 01/21/1998
• Status: Expired due to Term

• Current Assignee: Marc G. Apple, Melvin J. Apple
• Original Assignee: Marc G. Apple, Melvin J. Apple
• Inventors: Apple, Marc G., Apple, Melvin J.
• Primary Examiner(s): Smith, Jeffrey A.
• Assistant Examiner(s): Robert, Eduardo C.
• Application Number:
  US09/234,965
• Time in Patent Office: 607 Days
• Field of Search: 623/18, 623/16, 623/17, 623/19, 623/20, 623/21, 623/22, 623/23, 623/22.11, 623/17.12, 623/11.11, 623/16.11, 623/18.11, 623/23.11
• US Class Current: 623/11.11
• CPC Class Codes: A61F 2/0095 Packages or dispensers for prostheses or other implants for intraocular lenses A61F2/1691; for dental surgery A61C19/02
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/2803 for mandibular reconstruction temporo-mandibular joints A61F2/3099; bone plates for the jaw A61B17/8071
• CPC Class Codes: A61F 2/32 for the hip
• CPC Class Codes: A61F 2/34 Acetabular cups
• CPC Class Codes: A61F 2/36 Femoral heads ; Femoral endoprostheses
• CPC Class Codes: A61F 2/3609 Femoral heads or necks; Connections of endoprosthetic heads or necks to endoprosthetic femoral shafts A61F2/3601 takes precedence
• CPC Class Codes: A61F 2/3662 Femoral shafts
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2/4225 for feet, e.g. toes
• CPC Class Codes: A61F 2/4241 for hands, e.g. fingers
• CPC Class Codes: A61F 2002/30082 radioactive
• CPC Class Codes: A61F 2002/302 toroidal, e.g. rings
• CPC Class Codes: A61F 2002/30327 differing in diameter
• CPC Class Codes: A61F 2002/30581 having a pocket filled with fluid, e.g. liquid
• CPC Class Codes: A61F 2002/30584 filled with gas
• CPC Class Codes: A61F 2002/30718 Means for protecting prosthetic parts, e.g. during operation
• CPC Class Codes: A61F 2002/30731 Bone edge protectors
• CPC Class Codes: A61F 2002/30733 Inserts placed into an endoprosthetic cavity, e.g. for modifying a material property
• CPC Class Codes: A61F 2002/3081 : inclined obliquely with respect to each other
• CPC Class Codes: A61F 2002/30932 : for retarding or preventing ingrowth of bone tissue
• CPC Class Codes: A61F 2002/3611 : Heads or epiphyseal parts of femur
• CPC Class Codes: A61F 2002/3625 : Necks
• CPC Class Codes: A61F 2002/3631 : with an integral complete or partial peripheral collar or bearing shoulder at its base
• CPC Class Codes: A61F 2002/3647 : pierced with a longitudinal bore
• CPC Class Codes: A61F 2210/0095 : radioactive
• CPC Class Codes: A61F 2230/0065 : toroidal, e.g. ring-shaped, doughnut-shaped
• CPC Class Codes: A61F 2250/0039 : differing in diameter
• CPC Class Codes: A61K 51/1268 : host-guest, closed hollow molecules, inclusion complexes, e.g. with cyclodextrins, clathrates, cavitates, fullerenes
• CPC Class Codes: A61K 51/1282 : Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
• CPC Class Codes: A61N 5/1001 : using radiation sources introduced into or applied onto the body; brachytherapy
• CPC Class Codes: B82Y 5/00 : Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

An implant system and a method for delivering a dosage of radiation to targeted tissue. The system comprises a prosthetic device that functionally replaces or is additive to a body structure or joint, and a radio source material. The radio source material is positioned either on or within the prosthetic device. The actual radiation delivery distribution field has a similar configuration to the profile of the targeted tissue. The implant system is particularly useful for inhibiting heterotopic ossification.

Claims

1. An implant system for delivering a dosage of radiation to targeted tissue, the system comprising:

a prosthetic device for implantation and retention to natural bone tissue and adjacent to the targeted tissue; and

a radio source material disposed relative to the prosthetic device, the radio source material being part of the prosthetic device that is implanted, the radio source material being a non-chemical agent, any dispensation of the radio source material to the target tissue being minimal, the radio source material enabling radiation treatment to the targeted tissue, the radiation treatment being applied from the prosthetic device after implantation;

whereby a predetermined dosage of prescribed radiation to the targeted tissue is determined by using known physical characteristics of the radio source material and by controlling the placement of the radio source material relative to the targeted tissue.

2. The implant system of claim 1, wherein the radio source material is inserted during the implantation for the purpose of inhibiting complications caused by the implantation of the prosthetic device.

3. The implant system of claim 1, wherein the radio source material is inserted during the implantation for the purpose of preventing or treating heterotopic ossification.

4. The implant system of claim 1, further comprising a shield that protects nontargeted tissue from the radiation treatment.

5. The implant system of claim 1, wherein the radio source material is radio source fluid circulating within a plurality of interconnecting channels within the prosthetic device, the interconnecting channel being sealed once the radio fluid is disposed therein.

6. The implant system of claim 1, wherein the system minimizes the distribution of any radio source material into the targeted tissue.

7. A prosthetic device for delivering a dosage of radiation to targeted tissue, the prosthetic device having a function independent of radiation delivery, a radio source material being implanted with the prosthetic device, the implanted radio source material enabling a predetermined dosage of radiation treatment to be directed at the targeted tissue after implantation, the radio source material being designed to inhibit complications caused by the implantation of the prosthetic device, the dosage of prescribed radiation to the targeted tissue being predetermined by applying known physical characteristics of the radio source material and by controlling the placement of the radio source material relative to the targeted tissue.

8. The prosthetic device of claim 7, wherein the radio source material is prepackaged and secured to the prosthetic device that is implanted.

9. The prosthetic device of claim 7, wherein the radio source material is part of the prosthetic device that is implanted, the prosthetic device having a function independent of radiation delivery.

10. The prosthetic device of claim 7, wherein the radio source material is a nonchemical agent and the system avoids the distribution of radio source material into the targeted tissue.

11. A surgical method comprising:

introducing a prosthetic device including a radio source material, the prosthetic device and radio source material comprising a closed system for implantation within a patient, the prosthetic device having a function independent of radiation delivery, the radio source material being selected for delivering a predetermined dosage of the radiation from the radio source material to targeted tissue within a known profile, the profile of the targeted tissue being proximate to the implant site; and

implanting the prosthetic device into organic tissue during a surgical procedure, the radio source material in combination with the prosthetic device defining an actual radiation delivery distribution field, the actual radiation delivery distribution field having a similar configuration to the profile of the targeted tissue.

12. The surgical method of claim 11, further comprising applying the radiation treatment from the radio source material of the prosthetic device to the targeted tissue after implantation, the radio source material being a nonchemical agent and the system avoids the distribution of radio source material into the targeted tissue.

13. The surgical method of claim 11, further comprising selecting the radio source material having an emission profile that is generally the same as the targeted tissue.

14. An implant system for delivering a dosage of radiation to targeted tissue, the system comprising:

a prosthetic device for replacement of natural bone tissue and proximate to targeted tissue during a surgical procedure, the prosthetic device having a function independent of radiation delivery; and

a radio source material disposed about or within the prosthetic device, the radio source material being a non-chemical agent ant being selected for delivering a predetermined dosage of the radiation to the targeted tissue within a known profile, the known profile of the radio source material having an emission profile that is generally the same as the targeted tissue, the known profile being proximate to the implant site, the radio source material in combination with the prosthetic device defining an actual radiation delivery distribution field, the actual radiation delivery distribution field having a similar configuration to the known profile of the targeted tissue.

15. The implant system of claim 14, wherein the radio source material is for the purpose of preventing or treating of heterotopic ossification includes a radio nuclide selected from the group consisting of yttrium, strontium, iridium, iodine, palladium, and cesium, xenon, krypton, neon, argon, radon, technetium, rhenium, yttrium, phosphorus, iodine, strontium, samarium, gold, copper, palladium, iridium, tin, rubidium, osmium, platinum, Ytterbium, cesium, americium, radium, thallium, chromium, vanadium, barium, titanium, bismuth, and rhodium.

16. The implant system of claim 14, wherein the radio source material is a solid material disposed about the prosthetic device.

17. The implant system of claim 14, further comprising a shield that protects nontargeted tissue from the radiation treatment.

18. The implant system of claim 14, wherein the radio source material is part of the prosthetic device that is implanted, and any dispensation of the radio source material to the target tissue being minimal.

19. The implant system of claim 14, wherein the predetermined dosage of the radiation to the targeted tissue being between 10 to 500 cGy/hr.

20. A method for delivering prescribed radiation, the method comprising:

selecting a radio source material to deliver a confined and targeted tissue deposition of ionizing radiation for delivering a pre-calibrated dose rate, depth dose, and total delivered dose of prescribed radiation;

introducing a prosthetic device, the prosthetic device having a function independent of radiation delivery, the radio source material being selected to deliver the pre-calibrated dose rate, depth dose, and total delivered dose of prescribed radiation once implanted; and

delivering the pre-calibrated dose rate, depth dose, and total delivered dose of prescribed radiation to the targeted tissue after implantation;

whereby the radio source material is selected from the group consisting of yttrium, strontium, iridium, iodine, palladium, and cesium, xenon, krypton, neon, argon, radon, technetium, rhenium, yttrium, phosphorus, iodine, strontium, samarium, gold, copper, palladium, iridium, tin, rubidium, osmium, platinum, ytterbium, cesium, americium, radium, thallium, chromium, vanadium, barium, titanium, bismuth, and rhodium.