Water-stabilized organosilane compounds and methods for using the same

• US 6,120,587 A
• Filed: 05/20/1999
• Issued: 09/19/2000
• Est. Priority Date: 05/07/1997
• Status: Expired due to Term

• Current Assignee: Inhold LLC
• Original Assignee: Bioshield Technologies, Inc. (International Biochemical Industries, Inc.)
• Inventors: Moses, Timothy C., Elfersy, Jacques E., Berkner, Joachim
• Primary Examiner(s): BRUNSMAN, DAVID M
• Application Number:
  US09/315,573
• Time in Patent Office: 488 Days
• Field of Search: 106/18.35, 106/287.1, 106/287.14, 106/287.16, 514/63
• US Class Current: 106/18.35
• CPC Class Codes: C07F 7/1804 Compounds having Si-O-C linkages Si-O-acyl linkages C07F7/1896

Abstract

The composition formed by mixing an organosilane, optionally having a nonhydrolizable organic group, but having one or more hydrolyzable groups, with a polyol containing at least two hydroxy groups, wherein at least any two of the hydroxy groups are separated by no more than two intervening atoms. Water-stabilized organosilane compounds. A water stable composition made from the polyol and organosilane or compound and water. A method of treating a substrate by mixing or contacting the substrate with the product compound, or composition of this invention for a period of time sufficient for treatment of the substrate. A treated substrate having adhered thereto the product, compound, or composition of this invention. A method of dyeing and treating a substrate. A method of antimicrobially treating a food article. A method of antimicrobially coating a fluid container. A method of antimicrobially coating a latex medical article. A method of making a siloxane in the presence of a stabilizer.

Claims

1. A method of antimicrobially coating a fluid container used for containing a human or animal consumable product, comprising contacting the container with an effective amount of the composition formed from mixing:

a) an antimicrobial organosilane of the formula R_n SiX_4-n where n is an integer of from 0 to 3;

each R is, independently, a nonhydrolyzable organic group; and

each X is, independently, a hydrolyzable group;

with

b) a polyol containing at least two hydroxy groups, wherein any two of the at least two hydroxy groups are separated by no more than two intervening atoms, for a period of time sufficient to antimicrobially coat the container;

said composition being an aqueous solution wherein said organosilane amounts to about 20 percent or less, by weight percentage, of said composition.

3. The method of claim 1, wherein the article is a surgical glove.

2. A method of antimicrobially coating a latex medical article for use in a human or animal medical procedure, comprising contacting the article with an effective amount of the composition formed from mixing:

a) an antimicrobial organosilane of the formula R_n SiX_4-n where n is an integer of from 0 to 3;

each R is, independently, a nonhydrolyzable organic group; and

each X is, independently, a hydrolyzable group;

with

b) a polyol containing at least two hydroxy groups, wherein any two of the at least two hydroxy groups are separated by no more than two intervening atoms, for a period of time sufficient to antimicrobially coat the article;

said composition being an aqueous solution wherein said organosilane amounts to about 20 percent or less, by weight percentage, of said composition.

4. A method of antimicrobially treating a substrate selected from the group consisting of a concrete pipe, a tooth brush, a comb, a hair brush, a denture, an orthodontic retainer, a spa or pool filter, an air filter, an HVAC air system, a cabin air system, a marble article, a statue, an exposed work of art, an HDP plastic cover, a silicone or TEFLON®

coated fiberglass article, a Dryvitt finish, a stucco finish, blended cotton, a bio-film, a bio-adhesive, single ply roofing, a roofing shingle, a paper product, teeth, skin, bone, cartilage, a metal finish, a car finish, and a fiberglass reinforcement product, comprising contacting the substrate with an effective amount of the composition formed from mixing;

a) an antimicrobial organosilane of the formula R_n SiX_4-n where n is an integer of from 0 to 3;

each R is, independently, a nonhydrolyzable organic group; and

each X is, independently, a hydrolyzable group, with

b) a polyol containing at least two hydroxy groups, wherein any two of the at least two hydroxy groups are separated by no more than two intervening atoms, for a period of time sufficient to antimicrobially treat the substrate;

said composition being an aqueous solution wherein said organosilane amounts to about 20 percent or less, by weight percentage, of said composition.

5. A method of antimicrobially enhancing a product of rubbing alcohol, a flower preservative, or a waterproofing solution comprising admixing with the product an effective amount of the composition formed from mixing:

a) an antimicrobial organosilane of the formula R_n SiX_4-n where n is an integer of from 0 to 3;

each R is, independently, a nonhydrolyzable organic group; and

each X is, independently, a hydrolyzable group;

with

b) a polyol containing at least two hydroxy groups, wherein any two of the at least two hydroxy groups are separated by no more than two intervening atoms, for a period of time sufficient to antimicrobially enhance the product;

said composition being an aqueous solution wherein said organosilane amounts to about 20 percent or less, by weight percentage, of said composition.