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Method of using a small volume in vitro analyte sensor

  • US 6,120,676 A
  • Filed: 06/04/1999
  • Issued: 09/19/2000
  • Est. Priority Date: 02/06/1997
  • Status: Expired due to Term
First Claim
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1. A method of determining a concentration of an analyte in a sample, the method comprising steps of:

  • contacting the sample with an electrochemical sensor comprising a working electrode, a counter electrode, and a measurement zone bounded on at least two sides by the working electrode and counter electrode, wherein the measurement zone is sized to contain less than about 1 μ

    L of sample;

    holding the sample within the measurement zone in a non-flowing manner;

    applying a potential between the working and counter electrodes to electrolyze a portion of the analyte in the sample in the measurement zone;

    measuring current generated by the electrochemical sensor at a plurality of times while portion of the analyte is being electrolyzed; and

    determining, by coulometry, a concentration of the analyte in the sample using the measured currents.

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