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Method to detect bone and other connective tissue disorders in humans and animals

  • US 6,121,002 A
  • Filed: 06/06/1995
  • Issued: 09/19/2000
  • Est. Priority Date: 12/26/1990
  • Status: Expired due to Term
First Claim
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1. A method to diagnose the presence of a disorder associated with connective tissue metabolism abnormalities, which method comprisescomparing the level of native peptide-free crosslinks derived from collagen in a non-hydrolyzed biological fluid of a human subject with the level of said crosslinks in normal subjects so as to diagnose a subject having an enhanced level of said crosslinks as showing the presence of said disorder,wherein said crosslinks are selected from native non-glycosylated peptide-free pyridinoline (N-Pyd), native peptide-free deoxypyridinoline (N-Dpd), or a combination thereof.

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