Reduction of hair growth

• US 6,121,269 A
• Filed: 02/22/1999
• Issued: 09/19/2000
• Est. Priority Date: 02/22/1999
• Status: Expired due to Term

• Current Assignee: Gillette Company (The Procter & Gamble Company)
• Original Assignee: Gillette Company (The Procter & Gamble Company)
• Inventors: Henry, James P., Ahluwalia, Gurpreet S.
• Primary Examiner(s): Cook, Rebecca
• Application Number:
  US09/255,063
• Time in Patent Office: 575 Days
• Field of Search: 514/259, 514/295, 514/415, 514/520, 514/535, 514/567, 514/629
• US Class Current: 424/401
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/215 of carboxylic acids
• CPC Class Codes: A61K 31/275 Nitriles; Isonitriles
• CPC Class Codes: A61K 31/395 having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• CPC Class Codes: A61K 31/425 Thiazoles
• CPC Class Codes: A61K 8/66 Enzymes
• CPC Class Codes: A61Q 7/02 Preparations for inhibiting or slowing hair growth

Abstract

Mammalian hair growth is reduced by applying to the skin an inhibitor of protein-tyrosine kinase.

Claims

1. A method of reducing mammalian androgen-stimulated hair growth which comprises

selecting an area of skin from which reduced androgen-stimulated hair growth is desired;

and

applying to said area of skin a dermatologically acceptable composition comprising an inhibitor of protein-tyrosine kinase in an amount effective to reduce androgen-stimulated hair growth.

2. The method of claim 1, wherein the protein-tyrosine kinase is an EGF receptor.

3. The method of claim 1, wherein said inhibitor is lavendustin-A.

4. The method of claim 1, wherein said inhibitor is erbstatin.

5. The method of claim 1, wherein said inhibitor is a tryphostin.

6. The method of claim 1, wherein said inhibitor is piceatannol.

7. The method of claim 1, wherein said inhibitor is 4-hydroxybenzylidenemalononitrile.

8. The method of claim 1, wherein said inhibitor is 3,5-di-t-butyl-4-hydroxy-benzylidenemalononitrile.

9. The method of claim 1, wherein said inhibitor is α

-cyano-(3,4-dihydroxy)cinnamonitrile.

10. The method of claim 1, wherein said inhibitor is α

-cyano-(3,4,5-trihydroxy)cinnamonitrile.

11. The method of claim 1, wherein said inhibitor is α

-cyano-(3,4-dihydroxy)cinnamide.

12. The method of claim 1, wherein said inhibitor is α

-cyano-(3,4-dihydroxy)thiocinnamide.

13. The method of claim 1, wherein said inhibitor is 2-amino-4-(4'"'"'-hydroxyphenyl)-1,1,3-tricyanobuta-1,3-diene.

14. The method of claim 1, wherein said inhibitor is 2-amino-4-(3'"'"',4'"'"',5'"'"'-trihydroxyphenyl)-1,1,3-tricyanobuta-1,3-diene.

15. The method of claim 1, wherein said inhibitor is 2-amino-4-(1HA-indol-5-yl)-1,1,3-tricyanobuta-1,3-diene.

16. The method of claim 1, wherein said inhibitor is 4-hydroxy-3-methoxy-5-(benzothiazolythiomethyl) benzllidenecyanoacetamide.

17. The method of claim 1, wherein said inhibitor is 4-amino-N-(2,5-dihydroxybenzyl)methyl benzoate.

18. The method of claim 1, wherein said inhibitor is 4-(3-chloroanilino)-6,7-dimethoxyquinazoline.

19. The method of claim 1, wherein said inhibitor is α

-cyano-(3,4-dihydroxy)-N-benzylcinnamide.

20. The method of claim 1, wherein said inhibitor is (-)-R-N-(a-methylbenzyl)-3,4-dihdroxybenzylidenecyano acetamide.

21. The method of claim 1, wherein said inhibitor is α

-cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide.

22. The method of claim 1, wherein said inhibitor is α

-cyano-(3,4-dihydroxy)-N-phenylcinnamide.

23. The method of claim 1, wherein said inhibitor is α

-cyano-(+)-(S)-N-(α

-phenethyl)-(3,4-dihydroxy)cinnamide.

24. The method of claim 1, wherein said inhibitor is α

-cyano-(3,4-dihydroxy)-N-(phenylbutyl)cinnamide.

25. The method of claim 1, wherein said inhibitor is herbimycin A.

26. The method of claim 1, wherein said inhibitor, is a thiazolidine-dione.

27. The method of claim 1, wherein said inhibitor is phenazocine.

28. The method of claim 1, wherein said inhibitor is a 2,3-dihydro-2-thioxo-1H-indole-3-alkanoic acid.

29. The method of claim 1, wherein said inhibitor is a 2,2'"'"'-dithiobis-1H-indole-3-alkanoic acid.

30. The method of claim 1, wherein said inhibitor is a sulfonylbenzoyl-nitrostyrene.

31. The method of claim 1, wherein said inhibitor is methyl caffeate.

32. The method of claim 1, wherein said inhibitor is hydroxy-2-naphthalenylmethylphosphonic acid tris acetoxymethyl ester.

33. The method of claim 1, wherein the concentration of said inhibitor of said composition is between 0.1% and 30%.

34. The method of claim 1, wherein the inhibitor provides a reduction in hair growth of at least 20% when tested in the Human Hair Follicle Growth assay.

35. The method of claim 1, wherein the inhibitor provides a reduction in hair growth of at least 70% when tested in the Human Hair Follicle Growth assay.

36. The method of claim 1, wherein the inhibitor is applied to the skin in an amount of from 10 to 3000 micrograms of said inhibitor per square centimeter of skin.

37. The method of claim 1, wherein said mammal is a human.

38. The method of claim 37, wherein said area of skin is on the face of the human.

39. The method of claim 38, wherein the composition is applied to the area of skin in conjunction with shaving.

40. The method of claim 37, wherein said area of skin is on a leg of the human.

41. The method of claim 37, wherein said area of skin is on an arm of the human.

42. The method of claim 37, wherein said area of skin is in an armpit of the human.

43. The method of claim 37, wherein said area of skin in on the torso of the human.

44. The method of claim 1, wherein the composition is applied to an area of skin of a woman suffering from hirsutism.

45. The method of claim 1, wherein the composition further includes a second component that also causes a reduction in hair growth.

46. A method of reducing mammalian androgen-stimulated hair growth which comprises

inhibiting protein tyrosine kinase comprising applying to an area of skin from which reduced androgen-stimulated hair growth is desired an inhibitor of protein tyrosine kinase in an amount effective to reduce androgen-stimulated hair growth.