Device and process for regulating the sodium concentration in a dialysis liquid with a view to a prescription

• US 6,123,847 A
• Filed: 08/20/1998
• Issued: 09/26/2000
• Est. Priority Date: 08/21/1997
• Status: Expired due to Term

• Current Assignee: Industries Gambro
• Original Assignee: Hospal Industrie
• Inventors: Bene, Bernard
• Primary Examiner(s): Drodge, Joseph W.
• Application Number:
  US09/137,120
• Time in Patent Office: 768 Days
• Field of Search: 210/85, 210/87, 210/96.1, 210/103, 210/137, 210/321.65, 210/321.71, 210/646, 210/647, 210/739, 210/929, 210/96.2, 604/4-6, 604/65-67, 604/4.01, 604/5.01, 604/6.09, 604/6.11
• US Class Current: 210/646
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1607 before use, i.e. upstream of dialyser
• CPC Class Codes: A61M 1/1609 after use, i.e. downstream of dialyser
• CPC Class Codes: A61M 1/165 with a dialyser bypass on the dialysis fluid line
• CPC Class Codes: A61M 1/3437 downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3458 having electrolytes not present in the dialysate
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3324 PH measuring means
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir

Abstract

Dialysis apparatus including:

structure (14) for preparing a dialysis liquid containing sodium, comprising structure (18) for regulating the sodium concentration;

a dialysis liquid circuit comprising a feed line (12) and a discharge line (13), the feed line (12) having one end connected to the structure (14) for preparing dialysis liquid, and another end which can be connected to a dialyser (1), the discharge line (13) having an end which can be connected to the dialyser (1);

structure (9, 10, 12) for infusing a patient with an infusion solution containing sodium and a substance A at determined concentrations [Na⁺ ]sol and [A]sol;

structure (32) for determining the sodium concentration [Na⁺ ]dial of the dialysis liquid so that the patient'"'"'s body tends towards a desired sodium concentration [Na⁺ ]des, as a function of the dialysance D of the dialyser (1) for sodium, of the desired sodium concentration [Na⁺ ]des inside the patient'"'"'s body, of the infusion flow rate Qinf, and of the sodium concentration [Na⁺ ]sol of the infusion solution;

control structure (32) for driving the structure (18) for regulating the sodium concentration of the dialysis liquid such that this concentration is equal to the determined concentration [Na⁺ ]dial.

Claims

1. Dialysis apparatus comprising:

means for preparing a dialysis liquid containing sodium, comprising means for regulating the sodium concentration of the liquid;

a dialysis liquid circuit comprising a feed line and a discharge line, the feed line having one end connected to the means for preparing dialysis liquid, and another end which can be connected to a dialyser, the discharge line having an end which can be connected to the dialyser;

means for infusing a patient with an infusion solution containing sodium and a substance A at determined concentrations (Na⁺)sol and (A)sol;

means for determining the sodium concentration (Na⁺)dial of the dialysis liquid so that the patient'"'"'s body tends towards a desired sodium concentration (Na⁺)des, as a function of the dialysance D of the dialyser for sodium, of the desired sodium concentration (Na⁺)des inside the patient'"'"'s body, of the infusion flow rate Qinf, and of the sodium concentration (Na⁺)sol of the infusion solution;

control means for driving the means for regulating the sodium concentration of the dialysis liquid such that the concentration is equal to the determined concentration (Na⁺)dial.

2. Apparatus according to claim 1, wherein the means for determining the sodium concentration (Na⁺)dial of the dialysis liquid comprises calculation means for calculating the concentration according to the formula:

##EQU7##

3. Apparatus according to claim 1, further including means for determining the dialysance D of the dialyser for sodium.

4. Apparatus according to claim 3, wherein the means for determining the dialysance D of the dialyser for sodium compromises:

means for measuring the conductivity of the dialysis liquid upstream and downstream of the dialyser; and

means for calculating the dialysance D on the basis of at least two conductivity values measured respectively upstream and downstream of the dialyser in at least two successively prepared dialysis liquids.

5. Apparatus according to claim 4, wherein the means for calculating is configured to calculate the dialysance D of the dialyser for sodium according to the following formula:

##EQU8## where Qd is the flow rate of dialysis liquid.

6. Apparatus according to claim 5, wherein the means for determining the infusion flow rate Qinf comprises calculation means for calculating the infusion flow rate Qinf according to the formula:

##EQU9## where Cl is the clearance of the dialyser for the substance A.

7. Apparatus according to claim 1 comprising:

means for determining an infusion flow rate Qinf such that the concentration of the substance A inside the patient'"'"'s body tends towards a desired concentration (A)des;

means for regulating the infusion flow rate Qinf; and

control means for driving the means for regulating the infusion flow rate such that the flow rate is equal to the flow rate Qinf.

8. Process for regulating the sodium concentration of a dialysis liquid to a determined value (Na⁺)dial so that a patient'"'"'s body tends towards a desired sodium concentration (Na⁺)des, the patient'"'"'s blood and the dialysis liquid being circulated on either side of a semipermeable membrane of a dialyser, the patient furthermore receiving an infusion of a solution containing sodium and a substance A at determined concentrations (Na⁺)sol and (A)sol;

the process comprising the steps of;

determining the sodium concentration (Na⁺)dial of the dialysis liquid as a function of the dialysance D of the dialyser for sodium, of the desired sodium concentration (Na⁺)des inside the patient'"'"'s body, of the infusion flow rate Qinf, and of the sodium concentration (Na⁺)sol of the infusion solution; and

adjusting the sodium concentration of the dialysis liquid to the determined concentration (Na⁺)dial.

9. Process according to claim 8, wherein the step of determining the sodium concentration (Na⁺)dial of the dialysis liquid includes applying the formula:

##EQU10##10.

10. Process according to claim 8, further including the step of determining the dialysance D of the dialyser for sodium according to the steps of:

preparing and successively circulating through the dialyser at least two dialysis liquids having different conductivities;

taking at least two measurements of the conductivity of the at least two dialysis liquids upstream and downstream of the dialyser; and

calculating the dialysance D on the basis of the measured conductivity values (Cd1 in, Cd1out, Cd2in, Cd2out) of the at least two dialysis liquids.

11. Process according to claim 10, wherein the step of calculating the dialysance D of the dialyser for sodium includes applying the following formula:

##EQU11## where Qd is the flow rate of dialysis liquid.

12. Process according to claim 8, further comprising the steps of:

determining an infusion flow rate Qinf such that, at an end of a treatment session, the concentration of the substance A inside the patient'"'"'s body tends towards a desired concentration (A)des; and

adjusting the infusion flow rate to the determined flow rate Qinf.

13. Process according to claim 12, wherein the step of determining the infusion flow rate Qinf includes calculating the infusion flow rate Qinf according to the formula:

##EQU12## where Cl is the clearance of the dialyser for the substance A.

14. Process according to claim 13 wherein the clearance of the dialyser for the substance A is extrapolated from the dialysance D of the dialyser for sodium.

15. Process according to claim 8, wherein the substance A is bicarbonate.