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Diagnostic method and kit for neuropsychiatric diseases using trinucleotide repeats sequence

  • US 6,124,100 A
  • Filed: 02/22/1999
  • Issued: 09/26/2000
  • Est. Priority Date: 02/26/1998
  • Status: Expired due to Fees
First Claim
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1. A diagnostic method for detecting spinocerebellar ataxia type III ("SCA III III") syndrome, comprising the steps of:

  • attaching a portion (SEQ ID NO;

         3) of a spinocerebellar ataxia type III ("SCA III") gene containing copies of 73 trinucleotide (CAG) repeat units to a substrate;

    amplifying a DNA segment containing copies of the trinucleotide repeat units from the genomic DNA of a testee using two labeled primers (SEQ ID NO;

    1 and SEQ ID. NO;

         2) using a polymerase chain reaction (PCR) to produce a PCR product;

    hybridizing the SCA III gene with the PCR product; and

    analyzing the results of the hybridization.

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