Method of monitoring compliance with methadone treatment program
First Claim
1. A method of monitoring compliance of a patients that has been placed on a methadone maintenance program which comprises the steps of(a) obtaining a sample of the patient'"'"'s urine,(b) measuring the concentration of methadone, the specific gravity and the pH value of the urine sample,(c) calculating the concentration of methadone of the plasma as a function of the measured concentration of methadone of the urine, urine specific gravity, and urine pH, and(d) comparing the calculated concentration of methadone of the plasma with an expected value for the maintenance program prescribed.
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Abstract
A method of monitoring compliance of a patient that has been placed on a methadone maintenance program by determining plasma methadone concentration from urine methadone concentration. An unadulterated urine sample is obtained from the patient. The urine methadone concentration, pH, and specific gravity are measured. The plasma methadone concentration is calculated as a function of urine methadone concentration, specific gravity, and pH. The calculated plasma methadone concentration is compared with an expected value for the maintenance program prescribed.
21 Citations
16 Claims
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1. A method of monitoring compliance of a patients that has been placed on a methadone maintenance program which comprises the steps of
(a) obtaining a sample of the patient'"'"'s urine, (b) measuring the concentration of methadone, the specific gravity and the pH value of the urine sample, (c) calculating the concentration of methadone of the plasma as a function of the measured concentration of methadone of the urine, urine specific gravity, and urine pH, and (d) comparing the calculated concentration of methadone of the plasma with an expected value for the maintenance program prescribed.
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6. A method of monitoring compliance of a patient that has been placed on a methadone maintenance program with a prescribed methadone dose which comprises the steps of
(a) obtaining a sample of the patient'"'"'s urine, (b) measuring the concentration of methadone, the specific gravity and the pH value of the urine sample, (c) calculating a normalized urine methadone concentration as a function of the measured urine methadone concentration, prescribed methadone dose, urine specific gravity, and urine pH, and (d) comparing the present normalized urine methadone concentration with a previously determined historical base values for the patient'"'"'s normalized urine methadone concentration to verify compliance; whereby if the patient is in compliance with his/her prescribed dose, the present and historical base values of the patient'"'"'s normalized urine methadone concentration are similar. - View Dependent Claims (7, 8, 9, 10, 16)
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11. A method of determining plasma methadone concentration from urine which comprises the steps of
(a) obtaining a sample of the patient'"'"'s urine, (b) measuring the concentration of methadone, the specific gravity and the pH value of the urine sample, and (c) calculating the concentration of methadone of the plasma as a function of the measured concentration of methadone of the urine, urine specific gravity, and urine pH.
Specification