Method for treating ophthalmic disorders with IGFBP

• US 6,124,259 A
• Filed: 02/24/1998
• Issued: 09/26/2000
• Est. Priority Date: 01/28/1993
• Status: Expired due to Fees

• Current Assignee: Celtrix Pharmaceuticals, Inc. (Insmed Incorporated)
• Original Assignee: Celtrix Pharmaceuticals, Inc. (Insmed Incorporated)
• Inventors: Delmage, Michael J., Sommer, Andreas
• Primary Examiner(s): MOEZIE, FATEMEH T
• Application Number:
  US09/080,366
• Time in Patent Office: 945 Days
• Field of Search: 514/12, 530/350, 530/324, 435/69.1
• US Class Current: 514/8.5
• CPC Class Codes: A61K 38/1709 from mammals

Abstract

This is a method for treating ophthalmic disorders associated with an excess of IGF-I or IGF-II. The method comprises administering individuals with an IGF excess insulin-like growth factor binding protein (IGFBP). The preferred form is IGFBP-3.

Claims

1. A method for treating an individual who has undergone or is about to undergo or is undergoing ophthalmic surgery to promote healing without vision limiting scarring, said method comprising administering to said individual insulin-like growth factor binding protein-3 (IGFBP-3), said IGFBP-3 being administered in an amount sufficient to promote healing without vision limiting scaring, wherein said amount is administered by local or topical administration at 3 μ

g to 3 mg per eye.

2. The method of claim 1, wherein the IGFBP-3 is administered by direct application in the surgical wound.

3. The method of claim 1, wherein the IGFBP-3 is administered by intraocular injection.

4. The method of claim 1, wherein the IGFBP-3 is recombinant human IGFBP-3.

5. The method of claim 1, wherein the ophthalmic surgery is cataract extraction.

6. The method of claim 1, wherein the ophthalmic surgery is a corneal transplant.

7. The method of claim 1, wherein the ophthalmic surgery is surgery to correct refraction.

8. The method of claim 7, wherein the surgery to correct refraction is radial keratotomy.

9. The method of claim 1, wherein the ophthalmic surgery is glaucoma filtration surgery.

10. The method of claim 6 wherein the ophthalmic surgery is keratoplasty.

11. A method for treating an individual who has undergone, is about to undergo, or is undergoing corneal transplant surgery, comprising locally or topically administering 3 μ

g to 3 mg insulin-like growth factor binding protein-3(IGFBP-3) to said individual.

12. The method of claim 11, wherein the administration is performed by administration to the cornea or sclera.

13. The method of claim 12, wherein the application to the cornea or sclera is placement of timed release dosage form in the cul-de-sac.

14. The method of claim 11, wherein said IGFBP-3 is recombinant human IGFBP-3.