Non-aqueous polar aprotic peptide formulations
First Claim
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1. A stable non-aqueous formulation of a peptide compound comprising:
- a) at least one peptide compound; and
b) at least one polar aprotic solvent, wherein said polar aprotic solvent is selected from the group consisting of DMSO and DMF.
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Abstract
This invention relates to stable non-aqueous polar aprotic formulations of peptide compounds. These stable formulations comprise peptide in non-aqueous polar aprotic solvent. They may be stored at elevated temperatures for long periods of time and are especially useful in implantable delivery devices for long term delivery of drug.
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Citations
41 Claims
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1. A stable non-aqueous formulation of a peptide compound comprising:
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a) at least one peptide compound; and b) at least one polar aprotic solvent, wherein said polar aprotic solvent is selected from the group consisting of DMSO and DMF. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13)
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2. A stable non-aqueous formulation of a peptide compound comprising:
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a) at least one peptide compound; and b) at least one polar aprotic solvent, which is stable after irradiation. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22)
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3. A stable non-aqueous formulation of a peptide compound comprising:
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a) at least one peptide compound; and b) at least one polar aprotic solvent, which does not contain components containing added water. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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4. A stable non-aqueous formulation of a peptide compound comprising:
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a) at least one peptide compound; and b) at least one polar aprotic solvent, which exhibits bacteriostatic, bactericidal or sporicidal activity without the use of a conventional bacteriostatic, bactericidal or sporicidal agent, wherein said peptide compound is an LHRH-related compound. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41)
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Specification