Natural antioxidant compositions, method for obtaining same and cosmetic, pharmaceutical and nutritional formulations thereof

• US 6,124,268 A
• Filed: 02/17/1999
• Issued: 09/26/2000
• Est. Priority Date: 02/17/1999
• Status: Expired due to Term

• Current Assignee: Indian Herbs Research & Supply Company Ltd., Natreon, Inc.
• Original Assignee: Natreon, Inc.
• Inventors: Ghosal, Shibnath
• Primary Examiner(s): KRASS, FREDERICK F
• Application Number:
  US09/251,917
• Time in Patent Office: 587 Days
• Field of Search: 424/401, 424/439, 424/440, 424/195.1, 514/25, 514/27
• US Class Current: 514/27
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/522 Antioxidants; Radical scavengers
• CPC Class Codes: A61K 31/355 Tocopherols, e.g. vitamin E
• CPC Class Codes: A61K 31/366 having six-membered rings, e.g. delta-lactones
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61K 36/47 Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
• CPC Class Codes: A61K 38/063 Glutathione
• CPC Class Codes: A61K 8/498 having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61K 8/602 Glycosides, e.g. rutin
• CPC Class Codes: A61K 8/676 Ascorbic acid, i.e. vitamin C
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

A natural antioxidant blend in the form of an amphorous powder was obtained by extraction from Emblica officinalis fruit. In this process, the finely pulped fruit was treated with a dilute aqueous salt solution at hot water temperature to provide an extract-containing solution, which was filtered and dried to provide the desired antioxidant blend powder. Cosmetic, pharmaceutical and nutritional use formulations thereof also are described.

Claims

1. A process for producing an antioxidant blend from Emblica officinalis fruit comprising extracting the finely pulped fruit with a dilute aqueous or alcoholic-water salt solution at a temperature of about 70°

C.±

5°

C. to form an extract-containing solution, filtering, and drying to provide the desired antioxidant blend as a powder.

2. A process according to claim 1 wherein the dilute aqueous salt solution is a 0.1 to 5% solution of sodium chloride, potassium chloride, calcium chloride or magnesium chloride.

3. A process according to claim 1 wherein the dilute aqueous salt solution is a 0.1 to 5% buffered solution of sodium citrate/citric acid, sodium acetate/acetic acid or sodium phosphate/phosphoric acid.

4. A process according to claim 1 wherein drying is carried out by spray-drying or vacuum-drying.

5. A process according to claim 1 wherein the yield of the antioxidant blend is about 1 to 5% by weight of the pulp.

6. A process according to claim 1 wherein the antioxidant blend consists essentially of, by weight, (1) and (2) about 35-55% of the gallic/ellagic acid derivatives of 2-keto-glucono-δ

-lactone;

(3) about 4-15% of 2,3-di-O-galloyl-4,6-(S)-hexahydroxydiphenoylgluconic acid;

(4) about 10-20% of 2,3,4,6-bis-(S)-hexahydroxydiphenoyl-D-glucose;

(5) about 5-15% of 3'"'"',4'"'"',5,7-tetrahydroxyflavone-3-O-rhamnoglucoside; and

(6) about 10-30% of tannoids of gallic/ellagic acid.

7. An antioxidant blend obtained by the process of claim 1.

8. An antioxidant blend consisting essentially of, by weight, (1) and (2) about 35-55% of the gallic/ellagic acid derivatives of 2-keto-glucono-δ

-lactone;

(3) about 4-15% of 2,3-di-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-gluconic acid;

(4) about 10-20% of 2,3,4,6-bis-(S)-hexahydroxydiphenoyl-D-glucose;

(5) about 5-15% of 3'"'"',4'"'"',5,7-tetrahydroxyflavone-3-O-rhamnoglucoside; and

(6) about 10-30% of tannoids of gallic/ellagic acid.

9. A personal care, pharmaceutical or nutritional composition including the antioxidant blend of claim 8.

10. A composition according to claim 9 which contains about 0.05 to about 10% by wt. of said blend.

11. A skin care composition according to claim 9 in the form of a lotion, cream or gel.

12. A pharmaceutical composition according to claim 9 in the form of a tablet, syrup, elixir or capsule.

13. A nutritional composition according to claim 9 which contains about 0.05 to 5% of said blend.