Method for regulating hair growth
First Claim
Patent Images
1. A method for regulating hair growth comprising the administration to a human of a composition comprising about 0.00001% to about 99.9% of a compound selected from the group consisting of:
- a) lupane triterpenes having the structure;
##STR18## Where R1 is either
1) connected to the ring system via a single bond, either α
- or β
-configuration, and is selected from the group consisting of;
H, OH, R4, OR4, OCOR4, OCOOR4, OCONHR4, or OCON(R4)2 ;
halogen where R4 is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of;
i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen or sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR4, OCOR4, OCOOR4, OCONHR4, or OCON(R4)2 iii) OH, iv) OR4, v) OCOR4, vi) OCOOR4, vii) OCONHR4, or viii) OCON(R4)2 and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen or sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR4, OCOR4, OCOOR4, OCONHR4, or OCON(R4)2), or2) connected to the ring system via a double bond and is selected from the group consisting of a) oxygen, b) sulfur and c) R4,Where R2 is selected from the group consisting of;
CH3, CH2 OH, CH2 OR4, CHO, CO2 H, CO2 R4, COHNR4, CON(R4)2, CH2 OCOR4 where R4 is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of;
i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen or sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR4, OCOR4, OCOOR4, OCONHR4, or OCON(R4)2 iii) OH, iv) OR4, v) OCOR4, vi) OCOOR4, vii) OCONHR4, or viii) OCON(R4)2;
and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen or sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR4, OCOR4, OCOOR4, OCONHR4, or OCON(4)2;
And where R3 is selected from the group consisting of C(CH3)═
CH2, CH(CH3)2, COCH3, CH(OH)CH3, CH2 CH3, C(R5)(CH3)CH2 R5, or C(CH3)2 R5, CH(CH3)CH2 R5, where R5 is selected from the group consisting of OH and a halogen.
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Abstract
A method for regulating the growth and loss of hair via the use of compositions containing a compound selected from the group consisting of lupane triterpenes, derivatives of lupane triterpenes, derivatives of oleanane triterpenes, derivatives of ursane triterpenes, and salts and mixtures thereof.
95 Citations
10 Claims
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1. A method for regulating hair growth comprising the administration to a human of a composition comprising about 0.00001% to about 99.9% of a compound selected from the group consisting of:
-
a) lupane triterpenes having the structure;
##STR18## Where R1 is either
1) connected to the ring system via a single bond, either α
- or β
-configuration, and is selected from the group consisting of;
H, OH, R4, OR4, OCOR4, OCOOR4, OCONHR4, or OCON(R4)2 ;
halogen where R4 is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of;
i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen or sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR4, OCOR4, OCOOR4, OCONHR4, or OCON(R4)2 iii) OH, iv) OR4, v) OCOR4, vi) OCOOR4, vii) OCONHR4, or viii) OCON(R4)2 and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen or sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR4, OCOR4, OCOOR4, OCONHR4, or OCON(R4)2), or2) connected to the ring system via a double bond and is selected from the group consisting of a) oxygen, b) sulfur and c) R4, Where R2 is selected from the group consisting of;
CH3, CH2 OH, CH2 OR4, CHO, CO2 H, CO2 R4, COHNR4, CON(R4)2, CH2 OCOR4 where R4 is independently selected from the group consisting of a) cyclic, straight chain or branched chain, saturated or unsaturated, substituted or unsubstituted alkyl groups containing from 1-20 carbons, where the alkyl group, if substituted, is substituted with a substituent selected from the group consisting of;
i) halogens, ii) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen or sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR4, OCOR4, OCOOR4, OCONHR4, or OCON(R4)2 iii) OH, iv) OR4, v) OCOR4, vi) OCOOR4, vii) OCONHR4, or viii) OCON(R4)2;
and b) substituted or unsubstituted aryl groups comprising from 1 to 5 rings with or without heteroatoms, which heteroatoms are selected from the group consisting of nitrogen, oxygen or sulfur, where the aryl group, if substituted, is substituted with a substituent selected from the group consisting of halogens, alkyl groups, OH, OR4, OCOR4, OCOOR4, OCONHR4, or OCON(4)2;And where R3 is selected from the group consisting of C(CH3)═
CH2, CH(CH3)2, COCH3, CH(OH)CH3, CH2 CH3, C(R5)(CH3)CH2 R5, or C(CH3)2 R5, CH(CH3)CH2 R5, where R5 is selected from the group consisting of OH and a halogen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification
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Current AssigneeUniversity of Texas Southwestern Medical Center (University of Texas System)
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Original AssigneeThe Procter & Gamble Company
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InventorsBradbury, Barton James, Soper, Shari Joy, Gale, Celeste Dawn, Kaczvinsky, Joseph Robert Jr., Bailey, Dorothy Limerick
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Primary Examiner(s)Jarvis, William R.A.
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Assistant Examiner(s)KIM, VICKIE Y
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Application NumberUS09/353,408Time in Patent Office439 DaysField of Search514/569, 514/732US Class Current514/569CPC Class CodesA61K 2800/782 Enzyme inhibitors; Enzyme a...A61K 31/19 Carboxylic acids, e.g. valp...A61K 45/06 Mixtures of active ingredie...A61K 8/27 Zinc; Compounds thereofA61K 8/37 Esters of carboxylic acidsA61K 8/44 Aminocarboxylic acids or de...A61K 8/4946 Imidazoles or their condens...A61K 8/4953 containing pyrimidine ring ...A61K 8/63 Steroids; Derivatives thereofA61K 8/64 Proteins; Peptides; Derivat...A61K 8/9789 Magnoliopsida [dicotyledons]A61P 17/14 for baldness or alopeciaA61Q 7/00 Preparations for affecting ...A61Q 7/02 Preparations for inhibiting...
