Micro-system with an integrated cuvette for the analysis of liquids

• US 6,126,800 A
• Filed: 06/02/1998
• Issued: 10/03/2000
• Est. Priority Date: 06/06/1997
• Status: Expired due to Fees

• Current Assignee: Commissariat a L'Energie Atomique (French Alternative Energies and Atomic Energy Commission)
• Original Assignee: Commissariat a L'Energie Atomique (French Alternative Energies and Atomic Energy Commission)
• Inventors: Ponthenier, Gerard, Caillat, Patrice
• Primary Examiner(s): Tung, T.
• Application Number:
  US09/088,872
• Time in Patent Office: 854 Days
• Field of Search: 204/400, 204/416, 204/418, 204/419, 204/403, 204/415, 204/412
• US Class Current: 204/400
• CPC Class Codes: G01N 33/5438 Electrodes

Abstract

An analysis micro-system with integrated cuvette comprising:

a chip support (250) having at least one cuvette (252),

at least one chip (210) arranged in each cuvette, the chip comprising analysis electrodes (212) and addressing electrodes (214), and

connection means (258, 260, 262) to connect the addressing electrodes to at least one electrical apparatus external to the micro-system.

Conforming to the invention, the connection means comprise connection terminals (258) arranged on the support, outside the cuvette (252), and electrical links (260, 262) connecting the connection terminals (258) to the addressing electrodes.

Application to the analysis of chemical and biological products.

Claims

1. An analysis micro-system with integrated cuvette comprising:

(a) a chip support having at least one cuvette having a bottom and side walls, said chip support comprising (1) a first substrate forming said cuvette bottom and (2) a second substrate arranged on the first substrate and forming said side walls;

(b) at least one chip comprising analysis electrodes and addressing electrodes, said chip being positioned in said cuvette; and

(c) connection means to connect the addressing electrodes to at least one electrical apparatus external to the micro-system, said connection means comprising connection terminals arranged on said support outside said cuvette, and electrical links connecting said connection terminals to said addressing electrodes, said links arranged such that they pass between the first and second substrates.

2. A micro-system according to claim 1, in which the chip comprises a further substrate having said analysis and addressing electrodes, said further substrate being permanently fixed in the cuvette.

3. A micro-system according to claim 1, in which the chip is produced directly on the chip support.

4. A micro-system according to claim 1, comprising means for heating the chip.

5. A micro-system according to claim 4, in which the heating means comprise an electrical resistance integrated into the chip.

6. A micro-system according to claim 4, in which the heating means comprise an electrical resistance positioned under the chip.

7. A micro-system according to claim 1, in which the chip support comprises a thermocouple.

8. A micro-system according to claim 1, in which the addressing electrodes and the electrical links are insulated by an insulating encapsulation.

9. A micro-system according to claim 1 in which the cuvette has a volume determined in relation to a quantity of liquid required by the chip for processing.

10. A micro-system according to claim 1, including a sheet of glass arranged on the second substrate and covering the cuvette.

11. A micro-system according to claim 1, in which the support comprises a bulk substrate in which the cuvette is formed.