Contact-killing antimicrobial devices

• US 6,126,931 A
• Filed: 09/11/1998
• Issued: 10/03/2000
• Est. Priority Date: 12/20/1993
• Status: Expired due to Term

• Current Assignee: Biopolymerix, Inc., Surfacine Development Company LLC
• Original Assignee: Biopolymerix, Inc., Surfacine Development Company LLC
• Inventors: Yurkovetskiy, Alexander, Sawan, Samuel P., Subramanyam, Sundar
• Primary Examiner(s): Levy, Neil S.
• Application Number:
  US09/151,495
• Time in Patent Office: 753 Days
• Field of Search: 424/617, 424/618, 424/619, 424/630-643, 424/646-651, 424/663, 424/667-672, 424/78.09, 424/78.17, 424/78.34, 424/78.35, 424/404-407, 424/409 , 424/411-413, 424/431, 574/695, 574/634, 574/635, 523/132, 514/492-494, 514/499-503
• US Class Current: 424/78.09
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: B01D 2239/0442 Antimicrobial, antibacterial, antifungal additives apparatus incorporating such gas filtering material B01D46/0028
• CPC Class Codes: B01D 2239/0471 Surface coating material
• CPC Class Codes: B01D 2239/0478 on a layer of the filter
• CPC Class Codes: B01D 2239/086 Binders between particles or fibres
• CPC Class Codes: B01D 39/2037 otherwise bonded

Abstract

Contact killing antimicrobial articles, devices and formulations are described which kill microorganisms on contact. The articles, devices or formulations contain a non-leaching antimicrobial material which is a unique combination of an organic matrix having biocidal metallic materials non-leachably associated with the matrix. The antimicrobial material may used to form an antimicrobial coating or layer on a surface of the article or device, or may be dispersed in a vehicle or carrier to form a topical antiseptic or disinfectant, or solid shape having contact killing antimicrobial properties. When a microorganism contacts the article, device, or formulation, the biocidal metallic material is transferred to the microorganism in amounts sufficient to kill it.

Claims

1. A method of killing microorganisms comprising the steps of:

providing a substrate having disposed thereon a contact-killing, non-leaching antimicrobial coating, said coating comprising an organic polycationic polymer matrix having bound or complexed thereto a surface-accessible antimicrobial metallic material such that the antimicrobial coating does not release biocidal amounts of elutables into the surrounding environment; and

facilitating contact between the coating and the microorganism to permit direct transfer of the antimicrobial metallic material to the microorganism in an amount sufficient to kill the microorganism.

2. The method of claim 1 wherein the antimicrobial metallic material is selected from the group consisting of a metal, a metal salt, a metal complex, a metal alloy, and combinations thereof.

3. The method of claim 2 wherein said metal, metal salt, metal complex or a silver alloy is respectively, silver, a silver salt, a silver complex or a silver alloy.

4. The method of claim 2 wherein said metal salt is silver halide.

5. The method of claim 1 wherein the organic matrix comprises a biguanide polymer.

6. The method claim 5 wherein the biguanide compound comprises polyhexamethylene biguanide or its salts.

7. The method of claim 1 wherein the coating further comprises a cross-linking moiety comprising an organic compound containing functional groups selected from the group consisting of isocyanates, carboxylic acids, acid chlorides, acid anhydrides, succimidyl ethers aldehydes, aldehydes, ketones, alkyl methanesulfonates, alkyl trifluoromethanesulfonates, alkyl para-toluenemethanesulfonates, alkyl halides and epoxides.

8. The method of claim 1 wherein the substrate is selected from the group consisting of metal, wood, synthetic polymers, natural and synthetic fibers, cloth, paper, rubbers, and glass.

9. The method of claim 8 wherein said substrate is formed from a plastic selected from the group consisting of polysulfone, polyacrylate, polyethersulfone, polyamide, polycarbonate, polyvinylidene fluoride, polyethylene, polypropylene and cellulosics.

10. The method of claim 4 which said silver halide is silver iodide.

11. The method of claim 7 wherein said cross-linking moiety is N,N-methylene bisdiglycidylaniline.

12. The method of claim 5 wherein the biguanide compound comprises a polymer containing a biguanide moiety.