NPY antagonists
First Claim
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1. A compound of formula I, ##STR17## wherein Ar1 represents a structural fragment of the formula ##STR18## or represents 1- or 2-naphthyl, which latter group is optionally substituted by one or more substituents selected from OH, halo or C1-7 alkoxy;
- R1 represents C(O)NH2, C1-4 alkyl (optionally substituted or terminated by one or more substituents selected from hydroxy or amino), or, together withR7 (in Ar1), forms C2-3 alkylene;
R4 represents H, C1-7 alkyl or C1-4 alkylenephenyl (in which latter group, the phenyl group is optionally substituted by one or more substituent selected from OH or C1-4 alkoxy);
R5 and R6 independently represent H, OH, C1-4 alkyl, C1-4 alkoxy or halo;
R7 represents H, OH or, together with R1, forms C2-3 alkylene;
R8 represents H, halo, OH, C1-7 alkoxy, phenyl, phenoxy, benzyloxy, --CH2)n C(O)N(R10)R11, --(CH2)n N(H)C(O)N(R10)R11 or --O(CH2)n C(O)OR10 ;
R9 represents H, halo, OH or C1-7 alkoxy;
R2, R3, R10 and R11 independently represent H or C1-7 alkyl; and
n represents 1, 2, 3 or 4;
or a pharmaceutically acceptable derivative thereof.
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Abstract
There is provided pharmaceutically useful compounds of formula I, ##STR1## wherein Ar1, R1, R2, R3, R4, R5 and R6 have meanings given in the description, which are useful as antagonists of neuropeptide Y and in particular in the treatment of cardiovascular diseases, for example vasoconstriction.
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Citations
24 Claims
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1. A compound of formula I, ##STR17## wherein Ar1 represents a structural fragment of the formula ##STR18## or represents 1- or 2-naphthyl, which latter group is optionally substituted by one or more substituents selected from OH, halo or C1-7 alkoxy;
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R1 represents C(O)NH2, C1-4 alkyl (optionally substituted or terminated by one or more substituents selected from hydroxy or amino), or, together with R7 (in Ar1), forms C2-3 alkylene; R4 represents H, C1-7 alkyl or C1-4 alkylenephenyl (in which latter group, the phenyl group is optionally substituted by one or more substituent selected from OH or C1-4 alkoxy); R5 and R6 independently represent H, OH, C1-4 alkyl, C1-4 alkoxy or halo; R7 represents H, OH or, together with R1, forms C2-3 alkylene; R8 represents H, halo, OH, C1-7 alkoxy, phenyl, phenoxy, benzyloxy, --CH2)n C(O)N(R10)R11, --(CH2)n N(H)C(O)N(R10)R11 or --O(CH2)n C(O)OR10 ; R9 represents H, halo, OH or C1-7 alkoxy; R2, R3, R10 and R11 independently represent H or C1-7 alkyl; and n represents 1, 2, 3 or 4; or a pharmaceutically acceptable derivative thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification