Optical system for measuring metabolism in a body and imaging method
First Claim
1. A living body optical measurement method for measuring a living body transmitting light intensity with respect to a living body which experiences both load-induced-fluctuation and non-load-induced-fluctuation comprising:
- irradiating light on the living body while alternately setting a loading time during which a load is applied to the living body and an unloading time during which the load is not applied to the living body, wherein a relaxation time following the loading time is set, and a signal corresponding to a fluctuation attributable to the non-load-induced fluctuation of the living body and contained in a measured signal is estimated from a signal obtained during the unloading time exclusive of the relaxation time.
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Abstract
Light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. After completion of the measurement or during the measurement, changes in concentration values of absorbers in the living body are determined from the living body transmitting light intensity levels of the plurality of wavelengths detected at the respective detection points and a measuring point is set on a perpendicular extending through an intermediate point between the incident point and each detection point so as to image a function of the living body. In living body optical measurement system and method, the measuring time is shortened by estimating fluctuation attributable to the living body, the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time, and a local change in hemodynamic movement can be measured by detecting light rays transmitting through the interior of the living body by means of two means for light detection disposed at different two sites (equidistant from the light incident point) on a subject and by separating only the local change in hemodynamic movement from an overall change in hemodynamic movement in the living body in accordance with a logarithmic difference between the two detection signals.
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Citations
18 Claims
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1. A living body optical measurement method for measuring a living body transmitting light intensity with respect to a living body which experiences both load-induced-fluctuation and non-load-induced-fluctuation comprising:
irradiating light on the living body while alternately setting a loading time during which a load is applied to the living body and an unloading time during which the load is not applied to the living body, wherein a relaxation time following the loading time is set, and a signal corresponding to a fluctuation attributable to the non-load-induced fluctuation of the living body and contained in a measured signal is estimated from a signal obtained during the unloading time exclusive of the relaxation time. - View Dependent Claims (2, 3, 4, 5)
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6. A signal display method in a living body optical measurement system in which a living body transmitting light intensity is measured with respect to a living body which experiences both load-induced-fluctuation and non-load-induced-fluctuation comprising:
- irradiating light on a living body, and a measured signal or a signal resulting from calculation of the measured signal is displayed on a display unit, wherein a signal corresponding to fluctuation attributable to the non-load-induced-fluctuation over time of the living body and contained in the measured signal is estimated and the estimated signal is displayed together with the measured signal.
- View Dependent Claims (13, 16)
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7. A signal display method in a living body optical measurement system in which a living body transmitting light intensity is measured with respect to a living body which experiences both load-induced-fluctuation and non-load-induced-fluctuation, comprising:
- irradiating light on a living body while alternately setting a loading time during which a load is applied on the living body and an unloading time during which the load is not applied to the living body, and a measured signal or a signal calculated from the measured signal is displayed on a display unit, wherein a signal corresponding to fluctuation attributable to the non-load-induced-fluctuation of the living body and contained in the measured signal is estimated from a signal obtained during the unloading time, and the estimated signal, together with the measured signal, is displayed as an estimation non-load signal.
- View Dependent Claims (10, 11, 12, 14, 15, 17)
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8. A signal display method in a living body optical measurement system in which a living body transmitting light intensity is measured with respect to a living body which experiences both load-induced-fluctuation and non-load-induced-fluctuation, comprising:
- irradiating light on a living body while alternately setting a loading time during which a load is applied to the living body and an unloading time during which the load is not applied to the living body, and a measured signal or a signal calculated from the measured signal is displayed on a display unit, wherein a relaxation time following the loading time is set, a signal corresponding to fluctuation attributable to the non-load-induced-fluctuation of the living body and contained in the measured signal is estimated from a signal obtained during the unloading time exclusive of the relaxation time, and the estimated signal, together with the measured signal, is displayed as an estimation non-load signal.
- View Dependent Claims (9)
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18. A living body optical measurement method for measuring a living body transmitting light intensity with respect to a living body which experiences both load-induced-fluctuation and non-load-induced-fluctuation, comprising:
- irradiating light on the living body while alternately setting a loading time during which a load is applied to the living body and an unloading time during which the load is not applied to the living body, wherein a relaxation time following the loading time is set, and wherein the irradiating of light occurs over a plurality of periods of the loading time, unloading time and relaxation time, and a signal corresponding to a fluctuation attributable to the non-load-induced fluctuation of the living body and contained in a measured signal is estimated from a signal obtained over the plurality of periods but during the unloading time exclusive of the relaxation time.
Specification