Liquid chromatograph

• US 6,129,840 A
• Filed: 06/17/1999
• Issued: 10/10/2000
• Est. Priority Date: 06/19/1998
• Status: Expired due to Term

• Current Assignee: Shimadzu Corporation
• Original Assignee: Shimadzu Corporation
• Inventors: Kitaoka, Mitsuo
• Primary Examiner(s): Therkorn, Ernest G.
• Application Number:
  US09/334,913
• Time in Patent Office: 481 Days
• Field of Search: 210/635, 210/656, 210/659, 210/198.2, 210/101, 210/143, 73/61.55, 73/61.56
• US Class Current: 210/198.2
• CPC Class Codes: G01N 30/24 Automatic injection systems
• CPC Class Codes: G01N 30/34 of fluid composition, e.g. gradient G01N30/36 takes precedence

Abstract

When a signal for filling up with or substituting a mobile phase is externally transmitted to a control part, the control part switches a valve for connecting a channel from a pump part to a sampling needle through a sampling loop and moves the sampling needle toward a drain port. Thus, a channel is formed through a mobile phase container→a pump→the valve→the sampling loop→the sampling needle→the drain port. In this channel state, the control part drives the pump at a high speed for substituting the channel connecting the pump and the sampling needle by a desired mobile phase.

Claims

1. A liquid chromatograph comprising a column separating a sample, a feed part feeding a mobile phase to said column, a sample introduction part collecting said sample from a sampling needle into a sampling loop and introducing said collected sample into a mobile phase channel upstream said column by switching a channel switching valve, a detection part detecting said sample separated in said column and a control part controlling the operations of said feed part and said sample introduction part, said liquid chromatograph further comprising:

a drain port discharging a liquid discharged from said sampling needle outward, wherein

said control part switches said channel switching valve for connecting said feed part to a channel connecting said sampling needle through said sampling loop, locates said sampling needle on said drain port, and controls an operation switching said feed part to high-speed driving in addition to said control.

2. The liquid chromatograph in accordance with claim 1, wherein

said feed part has no outlet for directly discharging said mobile phase outward.

3. The liquid chromatograph in accordance with claim 1, wherein

said channel switching valve of said sample introduction part is a two-position valve switched between a position for connecting said feed part to said column through said sampling loop and a position for directly connecting said feed part to said column, and channel connection is so performed that a measuring member for collecting said sample is connected to said sampling loop on said position for directly connecting said feed part to said column.

4. The liquid chromatograph in accordance with claim 1, wherein

said channel switching valve of said sample introduction part is a three-position valve switched among a position for connecting said feed part to said column through said sampling loop, a position for directly connecting said feed part to said column and a position for connecting said feed part to said sampling loop and closing an upstream part of said column, and channel connection is so performed that a measuring member for collecting said sample is connected to said sampling loop on said position for directly connecting said feed part to said column.

5. The liquid chromatograph in accordance with claim 1, wherein

a plurality of mobile phase containers storing different mobile phases are connected to a suction side of said feed part through electromagnetic valves respectively so that said mobile phases can be selected by opening/closing said electromagnetic valves.