Template imprinted materials by RFGD plasma deposition

• US 6,131,580 A
• Filed: 04/15/1999
• Issued: 10/17/2000
• Est. Priority Date: 04/17/1998
• Status: Expired due to Fees

• Current Assignee: Washington University In St Louis
• Original Assignee: University of Washington
• Inventors: Shi, Huaiqiu, Ratner, Buddy D.
• Primary Examiner(s): Nguyen, Dinh X.
• Application Number:
  US09/293,460
• Time in Patent Office: 551 Days
• Field of Search: 128/898, 128/897, 623/11, 623/66, 623/11.11, 623/23.75, 623/23.76, 427/2.1, 427/2.24, 427/446, 427/447, 424/422
• US Class Current: 128/898
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/24 Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/30771 applied in original prostheses, e.g. holes or grooves
• CPC Class Codes: A61F 2/3094 Designing or manufacturing processes
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2002/0081 directly machined on the prosthetic surface, e.g. holes, grooves A61F2/30771 takes precedence
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues of bone tissue onto implantable joints A61F2002/3093
• CPC Class Codes: A61F 2002/30448 using adhesives
• CPC Class Codes: A61F 2002/30929 having at least two superposed coatings
• CPC Class Codes: A61F 2002/3093 for promoting ingrowth of bone tissue
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2240/001 Designing or manufacturing processes
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 33/0076 Chemical modification of the substrate
• CPC Class Codes: B05D 1/286 using a temporary backing to which the coating has been applied
• CPC Class Codes: B05D 1/62 Plasma-deposition of organic layers plasma deposition in general C23C14/00, C23C16/00

Abstract

Template-imprinted structures 10 are provided having at least one template-imprinted surface 12 defining indentations 14 that are capable of specifically binding cells and/or molecules, such as macromolecules including proteins, peptides and nucleic acids. Presently preferred embodiments of the template-imprinted structures include medical prostheses, such as artificial joints and heart valves, having surface indentations that specifically bind proteins and/or cells that enhance the biocompatibility of the prosthesis, thereby making it less likely that the prosthesis will be rejected by the body. Methods are also provided for making the template-imprinted structures of the present invention.

Claims

1. A method for forming a template-imprinted structure comprising:

(a) depositing a layer of sugar onto a first supporting surface bearing a plurality of templates;

(b) forming a plasma-deposited layer by depositing plasma onto said sugar layer;

(c) affixing said plasma-deposited layer to a second supporting surface; and

(d) removing said first supporting surface and said templates.

2. The method of claim 1 wherein said first supporting surface is selected from the group consisting of mica, glass and silicon wafer.

3. The method of claim 2 wherein said first supporting surface is mica.

4. The method of claim 1 wherein said templates are selected from the group consisting of cells, proteins, peptides and nucleic acids.

5. The method of claim 1 wherein said sugar is selected from the group consisting of trehalose, sucrose, lactose, mannose, maltose, fructose, glucose and galactose.

6. The method of claim 5 wherein the sugar is trehalose.

7. The method of claim 1 wherein said plasma-deposited layer is formed by a method selected from the group consisting of Radio Frequency Glow Discharge, direct current glow discharge plasma deposition, pulsed glow discharge plasma deposition and microwave glow discharge plasma deposition.

8. The method of claim 7 wherein said plasma-deposited layer is deposited by Radio Frequency Glow Discharge.

9. The method of claim 1 wherein said plasma-deposited layer is affixed to said second supporting surface by an adhesive.

10. The method of claim 9 wherein said adhesive is an epoxy resin.

11. The method of claim 1 wherein said second supporting surface is a surface of a medical prosthesis.

12. The method of claim 1 wherein said second supporting surface is a surface of a microchip.