Intima-media thickness measuring apparatus and arterial sclerosis diagnosing system

• US 6,132,373 A
• Filed: 05/14/1999
• Issued: 10/17/2000
• Est. Priority Date: 05/18/1998
• Status: Expired due to Fees

• Current Assignee: Masao Ito, Yoshimitsu Yamasaki
• Original Assignee: Masao Ito, Yoshimitsu Yamasaki
• Inventors: Ito, Masao, Yamasaki, Yoshimitsu
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US09/311,734
• Time in Patent Office: 522 Days
• Field of Search: 600/437, 600/440, 600/441, 600/447, 600/449, 600/450, 600/455-456, 600/463, 600/466-467
• US Class Current: 600/437
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 8/0858 involving measuring tissue layers, e.g. skin, interfaces
• CPC Class Codes: A61B 8/0891 for diagnosis of blood vessels
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

An apparatus for measuring an intima-media thickness of a blood vessel is disclosed. The apparatus includes: an ultrasound device for outputting digital image data representing an image of the blood vessel produced by scanning the blood vessel with an ultrasound; and a data analyzing device for receiving the output digital image data and calculating the intima-media thickness of the blood vessel according to the received digital image data. The digital image data includes a plurality of luminance values each corresponding to respective one of a plurality of pixels of the image. The data analyzing device includes: a setting device for setting a base position between a center of the blood vessel and a position in a vicinity of an inner intima wall of the blood vessel on the image, on the basis of a moving average of the luminance values; and a calculation device for detecting a maximum value and a minimum value from among the luminance values respectively corresponding to a predetermined number of the pixels arranged from the base position toward a position of an outer adventitial wall on the image, and calculating the intima-media thickness on the basis of the maximum value and the minimum value.

Claims

1. An apparatus for measuring an intima-media thickness of a blood vessel, comprising:

an ultrasound device for outputting digital image data representing an image of the blood vessel produced by scanning the blood vessel with an ultrasound, the digital image data including a plurality of luminance values each corresponding to respective one of a plurality of pixels of the image; and

a data analyzing device for receiving the output digital image data and calculating the intima-media thickness of the blood vessel according to the received digital image data,

wherein the data analyzing device comprises;

a setting device for setting a base position between a center of the blood vessel and a position in a vicinity of an inner intima wall of the blood vessel on the image, on the basis of a moving average of the luminance values; and

a calculation device for detecting a maximum value and a minimum value from among the luminance values respectively corresponding to a predetermined number of the pixels arranged from the base position toward a position of an outer adventitial wall on the image, and calculating the intima-media thickness on the basis of the maximum value and the minimum value.

2. The apparatus according to claim 1, wherein the setting device comprises a base position setting device for setting a position at which an increasing rate of the luminance values exceeds a predetermined rate as the base position.

3. The apparatus according to claim 1, wherein the thickness calculation device comprises:

a first detection device for detecting a first maximum value from among the luminance values respectively corresponding to the predetermined number of the pixels arranged from the base position toward the position of the outer adventitial wall on the image, and detecting a position of the pixel corresponding to the first maximum value as a first position;

a second detection device for detecting a second maximum value from among the luminance values respectively corresponding to the pixels arranged between the base position and the first position, and detecting a position of the pixel corresponding to the second maximum value as a second position;

a third detection device for detecting a third position at which a change of the luminance values is changed over from decrease to increase by scanning the change of the luminance values from the second position toward the center of the blood vessel, and setting the third position as a position of an inner intimal wall of the blood vessel on the image;

a fourth detection device for detecting a first minimum value from among the luminance values respectively corresponding to the pixels arranged between the first position and the second position, and detecting a position of the pixel corresponding to the first minimum value as a fourth position;

a first calculation device for calculating a position of an inner adventitial wall by using a value representing the first position and a value representing the fourth position; and

a second calculation device for calculating a difference between a value representing the position of an inner intimal wall and a value representing the position of an inner adventitial wall, thereby obtaining the intima-media thickness.

4. The apparatus according to claim 3, wherein the first calculation device calculates the position of the inner adventitial wall according to an equation:

space="preserve" listing-type="equation">Xb=(MPX-MX)/2+MX,

where the Xb is a value representing the position of the inner adventitial wall, the MPX is a value representing the first position, the MX is a value representing the fourth position.

5. The apparatus according to claim 3, wherein the thickness calculation device comprises:

a first collecting device for collecting a plurality of values each representing the position of the inner intimal wall of the blood vessel on the image, by carrying out a detection of the position of the inner intimal wall a plurality of times at a plurality of different detecting positions, while shifting the detection position in a direction along an axis of the blood vessel;

a third calculation device for calculating a first regression curve by using the plurality of values collected by the first collection device;

a second collecting device for collecting a plurality of values each representing the position of the inner adventitial wall of the blood vessel on the image, by carrying out a detection of the position of the inner adventitial wall a plurality of times on a plurality of different detecting positions, while shifting the detection position in a direction along an axis of the blood vessel;

a fourth calculation device for calculating a second regression curve by using the plurality of values collected by the second collection device;

a fifth calculation device for calculating a plurality of thickness values respectively representing the intima-media thickness at the plurality of difference detection positions, on the basis of differences between the first regression curve and the second regression curve; and

an average device for calculating an average of a maximum value among the plurality of thickness values and at least two of the plurality of thickness values except for the maximum value.

6. The apparatus according to claim 5, wherein the fifth calculation device calculates at least one of the plurality of thickness values by using a tangent of at least either one of the first regression curve and the second regression curve.

7. The apparatus according to claim 1, wherein the ultrasound device outputs a plurality of digital image data, the data analyzing device calculates the intima-media thickness of the blood vessel according to the plurality of digital image data, and the plurality of image data are obtained by scanning a part of the blood vessel with the ultrasound while changing a position from which the ultrasound is radiated.

8. The apparatus according to claim 1 further comprising:

a storage device for storing data representing intima-media thickness with respect to a plurality of examinees or patients; and

an evaluation table generating device for generating an evaluation table in which data indicating averages and distributions of the intima-media thickness for each age of the examinees or patients are described.

9. The apparatus according to claim 1 further comprising an optically coupled device for optically connecting between the ultrasound device and the data analyzing device.