Intramyocardial anomalous activity detection by subtracting modeled respiratory effect
First Claim
1. An apparatus for detecting repeating patterns of anomalous Intramyocardial electrical activity in the heart of a patient, comprising:
- (a) means for obtaining data on an electrical potential that includes a cardiac component and a respiratory component;
(b) means for obtaining respiratory data from the body; and
(c) processor electrically associated with the means for obtaining electrical potential data and with the means for obtaining respiratory data, the processor regressing the electrical potential data on the respiratory data to estimate the respiratory component in the electrical potential, said processor aligning the electrical potential data by heart beats and statistically modeling the respiratory data with the electrical potential data in alignment across multiple heart beats the processor also determining whether anomalous Intramyocardial activity is present by finding the difference between the electrical potential data and the estimated respiratory component.
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Accused Products
Abstract
A technique of detecting repeating patterns of anomalous intramyocardial Wenckebach electrical activity in a patient is provided. The method of the technique deals with determining the presence or absence of such intramyocardial anomaly by processing signals that are electrical potential signals which include a cardiac component and a respiratory component. The method includes estimating the respiratory component (preferably by a regression curve-fitting technique based on data of the electrical potential signals and data of respiratory signals), finding the difference between the electrical potential and the estimated respiratory component and based on this difference inferring the presence of absence of the intramyocardial anomaly. Preferably, a generalized inverse of a matrix representing Wenckebach basis functions reflecting Wenckebach phases and modes is used to act on a vector representing the difference between the electrical potential and the estimated respiratory component to determine whether any repeating intramyocardial electrical anomaly is present.
23 Citations
28 Claims
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1. An apparatus for detecting repeating patterns of anomalous Intramyocardial electrical activity in the heart of a patient, comprising:
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(a) means for obtaining data on an electrical potential that includes a cardiac component and a respiratory component; (b) means for obtaining respiratory data from the body; and (c) processor electrically associated with the means for obtaining electrical potential data and with the means for obtaining respiratory data, the processor regressing the electrical potential data on the respiratory data to estimate the respiratory component in the electrical potential, said processor aligning the electrical potential data by heart beats and statistically modeling the respiratory data with the electrical potential data in alignment across multiple heart beats the processor also determining whether anomalous Intramyocardial activity is present by finding the difference between the electrical potential data and the estimated respiratory component. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 24, 25)
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11. A method for detecting repeating patterns of anomalous Intramyocardial activity, comprising:
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(a) providing electrical potential data that include a cardiac component and a respiratory component; (b) regressing the electrical potential data on respiratory data to estimate the respiratory component, by aligning the electrical potential data by heart beats and statistically modeling the respiratory data with the electrical potential data in alignment across multiple heart beats; and (c) determining the presence or absence of intramyocardial anomaly by finding the difference between the electrical potential data and the estimated respiratory component and detecting periodically repeating intramyocardial anomaly in the difference. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 26)
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27. An apparatus for detecting repeating patterns of anomalous intramyocardial electrical activity in the heart of a patient, comprising:
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(a) means for obtaining data on an electrical potential that includes a cardiac component and a respiratory component; (b) means for obtaining respiratory data from the body; and (c) processor electrically associated with the means for obtaining electrical potential data and with the means for obtaining respiratory data, the processor regressing the electrical potential data on the respiratory data to estimate the respiratory component in the electrical potential, the processor also determining whether anomalous intramyocardial activity is present by finding the difference between the electrical potential data and the estimated respiratory component, wherein the processor calculates the vector of Wenckebach basis function strengths x by a relationship in which the nonsingular Wenckebach matrix W, a vector b of cardiac electrical potential data obtained from the electrical potential data, and the vector of Wenckebach basis function strengths x are related by x=WI b , where the WI represents the generalized inverse of the matrix W.
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28. An article of manufacture comprising a program storage medium, tangibly embodying a program code means readble by a computer to cause the computer to analyze for repeating patterns of anomalous intramyocardial activity of a patient, the computer readable program code means in the article of manufacture including:
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(a) code means for regressing electrical potential data of the patient on respiratory data of the patient to estimate a respiratory component in the electrical potential data, the electrical potential data including a cardiac component and a respiratory component; (b) code means for generating a vector b by determining the difference between the electrical potential data and the estimated respiratory component; (c) code means for generating a nonsingular Wenckebach matrix W describing patterns of Wenckebach activity; and (d) code means for determining a vector of Wenckebach basis function strengths x based on the nonsingular Wenckebach matrix W and the vector b of said difference to determine the presence or absence of repeating patterns of Wenckebach activity, wherein the vector of Wenckebach basis finction strengths x indicating the intensity of Wenckebach activity.
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Specification