Needleless syringe with prefilled cartridge

• US 6,132,395 A
• Filed: 12/08/1998
• Issued: 10/17/2000
• Est. Priority Date: 12/08/1998
• Status: Expired due to Term

• Current Assignee: Bioject Incorporated
• Original Assignee: Bioject Incorporated
• Inventors: Landau, Sergio, Bonicatto, James M.
• Primary Examiner(s): Kennedy, Sharon
• Assistant Examiner(s): KLINE, ERIC E
• Application Number:
  US09/207,398
• Time in Patent Office: 679 Days
• Field of Search: 604/118, 604/131, 604/121, 604/140, 604/141, 604/146, 604/156, 604/218, 604/231, 604/232, 604/236, 604/238, 604/249, 604/264, 604/68
• US Class Current: 604/68
• CPC Class Codes: A61M 2005/2462 by displacing occluding plugs
• CPC Class Codes: A61M 2005/287 by displacing occluding plugs
• CPC Class Codes: A61M 2005/3106 Plugs for syringes without needle
• CPC Class Codes: A61M 2005/3123 having air entrapping or venting means, e.g. purging channels in pistons
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2005/3132 having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/2459 upon internal pressure increase, e.g. pierced or burst A61M5/2429 takes precedence
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

A cartridge and nozzle assembly for use in a needless injection system is provided. The assembly includes: (1) a cartridge having a plunger disposed at a rearward end thereof, and including a throat at a forward portion thereof, with a displaceable outlet valve initially disposed within the throat, the outlet valve being formed of resilient material and having at least one axial channel defined in the forward and rearward portions thereof, between which is disposed a channel-less valve body; (2) a nozzle for receiving the cartridge, the nozzle defining a rearward, cartridge-receiving portion, and including a forward portion terminating in and defining a valve abutment surface with an injection orifice defined therein and a recessed portion, the recessed portion being configured to receive the valve when the valve is displaced to a forwardly disposed position such that the valve is disposed against the valve abutment surface, and so that the inner portion of the cartridge has fluid access to the orifice via the axial channels and around the valve body; and (3) a seal disposed between the cartridge and the nozzle adjacent the forward portions thereof for at least reducing leakage of injectate therebetween.

Claims

1. A cartridge and nozzle assembly for use in a needleless injection system, comprising:

a cartridge having a plunger disposed at a rearward end thereof, and including a throat at a forward portion thereof, the cartridge further including a generally laterally extending interface surface;

a displaceable outlet valve initially disposed within the cartridge throat, the outlet valve being formed of resilient material;

a nozzle for receiving the cartridge, the nozzle defining a rearward, cartridge-receiving portion, and including a forward portion terminating in and defining a valve abutment surface with an injection orifice defined therein, the forward portion being configured to receive the valve when the valve is displaced to a forwardly disposed position such that the valve is disposed against the valve abutment surface, with a plurality of channels providing fluid access between the cartridge throat and the injection orifice when the valve is in its forwardly disposed position, the nozzle further including a generally laterally extending interface surface which abuts the cartridge interface surface; and

a seal disposed between the cartridge and the nozzle rearward of the interface surfaces for at least reducing leakage of injectate therebetween.

2. The assembly of claim 1, wherein the cartridge includes a peripheral seal positioned over at least a portion of the outlet valve for retaining the outlet valve in place to keep the cartridge closed and sealed until the cartridge is sufficiently pressurized.

3. The assembly of claim 2 wherein the outlet valve includes a radially extending portion adjacent the forward portion thereof, at least a part of the radially extending portion being covered by the peripheral seal when the outlet valve is in its closed position.

4. The assembly of claim 3 wherein the radially extending portion includes a weakened region disposed radially inwardly of the peripheral seal which is subject to tearing to permit the outlet valve to shift forwardly to open the cartridge.

5. The assembly of claim 1 wherein the cartridge throat is tapered and the seal is mounted in a gap defined between the cartridge and the nozzle, adjacent to the cartridge throat.

6. The assembly of claim 1 wherein the valve abutment surface includes a shoulder extending perpendicular to the path of travel of the valve, and the valve includes a complementary surface which also extends perpendicular to the path of travel of the valve.

7. The assembly of claim 1 wherein the rearward portion of the outlet valve extends at least partially into the cartridge throat when the forward portion thereof is disposed against the abutment surface.

8. The assembly of claim 1 wherein the cartridge is formed of glass.

9. The assembly of claim 1 wherein the valve is sized to be friction fit within the cartridge throat, and the valve includes a channel-less valve body adopted to be fit against the cartridge throat when the valve is in its initial position.

10. The assembly of claim 9 wherein the seal is disposed rearwardly of the initial position of the valve body.

11. The assembly of claim 1 wherein the cartridge throat includes a rearward end, and the seal is disposed in alignment with the rearward end of the cartridge throat.

12. The assembly of claim 1 wherein the outlet valve has a channel-less valve body so that the throat is sealed when the valve is disposed within the throat.

13. The assembly of claim 1 wherein the plurality of channels are formed in the outlet valve.

14. The assembly of claim 1 wherein the cartridge interface surface is generally forwardly facing, and the nozzle interface surface is generally rearwardly facing.

15. A method of providing a needleless injection system, comprising:

selecting a resilient valve member;

selecting a cartridge having laterally facing side walls, a forward throat conforming to the body of the valve;

placing the valve within the cartridge throat;

filling the cartridge with liquid injectate;

installing a plunger in the rear end of the cartridge;

selecting a nozzle with laterally facing side walls, a rearward cartridge-receiving portion and a forward portion defining a recess for non-sealably receiving the valve such that a plurality of channels are defined between the valve and the nozzle, the nozzle further including an orifice for facilitating injection of injectate therethrough;

selecting a cartridge/nozzle seal member;

installing the cartridge into the nozzle to form a cartridge/nozzle assembly, with the seal member disposed between the side walls of the cartridge and nozzle; and

mounting the cartridge/nozzle assembly into a needleless injection system by pushing the plunger rearwardly against a ram to forwardly displace the plunger, causing pressure of injectate within the cartridge to forwardly displace the valve into the nozzle recess to permit injectate to flow through the channels, and into the orifice.

16. The method of claim 15, further comprising:

subsequently having the ram exert injection pressure on the plunger to force injectate from the cartridge, through the channels and through the aperture and into the patient.

17. The method of claim 15 wherein the step of selecting the valve involves selecting a valve having a radially-outwardly extending surface with a tearable portion defined therein, and wherein the step of pushing the plunger and causing pressure to forwardly displace the valve involves tearing the tearable portion and thereby permitting the valve to be forwardly displaced.