Production of lenticular tablets by melt calendering

• US 6,132,659 A
• Filed: 06/20/1997
• Issued: 10/17/2000
• Est. Priority Date: 12/23/1994
• Status: Expired due to Term

• Current Assignee: Abbvie Deutschland GmbH & Company KG (Abbvie Incorporated)
• Original Assignee: BASF AG (BASF SE)
• Inventors: Breitenbach, Jorg, Rosenberg, Joerg, Maier, Werner
• Primary Examiner(s): THEISEN, MARY LYNN F
• Application Number:
  US08/860,019
• Time in Patent Office: 1,215 Days
• Field of Search: 264/141, 264/140, 425/363, 424/467, 424/464
• US Class Current: 264/140
• CPC Class Codes: A61J 2200/20 Extrusion means, e.g. for producing pharmaceutical forms
• CPC Class Codes: A61J 3/10 into the form of compressed tablets tablet presses B30B11/00
• CPC Class Codes: A61K 9/2072 characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms A61K9/0004, A61K9/0056, A61K9/0065 take precedence
• CPC Class Codes: B30B 11/165 Roll constructions

Abstract

The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.

Claims

1. A process for the production of lenticular tablets, which process comprises:

molding a melt in a calender until tablets are formed;

said melt comprising an active ingredient;

said calender comprising counter-rotating molding rolls which have on their surface a plurality of mutually opposite depressions in the shape of segments of an ellipsoid for receiving and molding the melt; and

wherein the angle between the tangential surface of each depression at the upper edge and the surface of the molding roll is <

90°

; and

then deflashing the tablets.

2. A process as claimed in claim 1, wherein at least one molding roll which has depressions in the shape of segments of a sphere is used.

3. A process as claimed in claim 1, wherein molding rolls provided with a release agent are used.

4. A process as claimed in claim 1, wherein a melt which contains an active ingredient and which comprises at least one pharmaceutically acceptable, water-soluble polymer is used.

5. A process as claimed in claim 1, wherein polyvinylpyrrolidone, a copolymer of N-vinylpyrrolidone and a vinyl ester, copolymers of vinyl acetate and crotonic acid, partially hydrolyzed polyvinyl acetate, polyvinyl alcohol, an ethylene/vinyl acetate copolymer, poly(hydroxyethyl methacrylate), copolymers of methyl methacrylate and acrylic acid, cellulose eaters, cellulose ethers or polyethylene glycol is used as polymer.

6. A process as claimed in claim 1, wherein at least one molding roll in which the depressions are divided by at least one bar which extends essentially up to the surface of the molding roll and forms a score is used.

7. The process of claim 1, wherein the angle between the tangential surface of the depression at the upper edge and the surface of the molding rolls is <

45°

.

8. A calender molding roll having on its surface a plurality of depressions in the shape of segments of an ellipsoid;

said depressions having an upper edge;

wherein the angle between the tangential surface of each depression at the upper edge and the surface of the molding roll is <

90°

.

9. The calender molding roll defined in claim 8, wherein the angle between the tangential surface of the depression at the upper edge and the surface of the molding roll is <

45°

.

10. The calender molding roll defined in claim 8, wherein said depressions are in the shape of a sphere.

11. A calender molding roll as claimed in claim 8, wherein the depressions are divided by at least one bar which extends up to the surface of the molding roll.