Electrochemical analyte
DCFirst Claim
1. An analyte responsive electrochemical sensor comprising a working electrode and a mass transport limiting membrane, which mass transport limiting membrane maintains a rate of permeation of the analyte through the mass transport limiting membrane with a variation of no more than 3% per °
- C. at temperatures ranging from 30°
C. to 40°
C.
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Abstract
An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.
1906 Citations
29 Claims
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1. An analyte responsive electrochemical sensor comprising a working electrode and a mass transport limiting membrane, which mass transport limiting membrane maintains a rate of permeation of the analyte through the mass transport limiting membrane with a variation of no more than 3% per °
- C. at temperatures ranging from 30°
C. to 40°
C. - View Dependent Claims (2, 3, 4)
- C. at temperatures ranging from 30°
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5. An electrochemical sensor, comprising:
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a substrate; and a working electrode disposed on the substrate, the working electrode comprising a carbon material and having a width along at least a portion of the working electrode of 150 μ
m or less. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. An electrochemical sensor, comprising:
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a substrate; a conductive material disposed on the substrate to form a working electrode; catalyst dispersed in the conductive material, the catalyst catalyzing a reaction of the analyte to generate a signal at the working electrode; and a binder dispersed in the conductive material wherein the binder is cured so that the catalyst and conductive material are non-leachably disposed on the substrate.
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29. An implantable electrochemical sensor, comprising:
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a substrate having a longitudinal axis with a narrow distal region that is configured and arranged for implantation into an animal and a wider proximal region that extends in a single lateral direction from the longitudinal axis; at least one working electrode disposed on the narrow distal region of the substrate; and at least one contact pad disposed on the wider proximal region of the substrate and in electrical communication with a one of the at least one working electrodes.
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Specification