Apparatus and methods for determining spatial coordinates of radiolabeled tissue using gamma-rays and associated characteristic x-rays

• US 6,135,955 A
• Filed: 10/27/1997
• Issued: 10/24/2000
• Est. Priority Date: 04/28/1995
• Status: Expired due to Term

• Current Assignee: Southern Scientific Limited (Lablogic Systems Ltd.)
• Original Assignee: Care Wise Medical Products Corporation
• Inventors: Pehl, Richard, Madden, Norman, McKellar, Louis, Carroll, Robert G.
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US08/958,417
• Time in Patent Office: 1,093 Days
• Field of Search: 600/436, 600/407, 600/1, 250/363.02, 250/363.1, 250/363.07
• US Class Current: 600/436
• CPC Class Codes: A61B 2090/392 Radioactive markers
• CPC Class Codes: A61B 6/4057 by using radiation sources located in the interior of the body A61B6/037 takes precedence
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 6/482 involving multiple energy imaging
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00

Abstract

A system and method for diagnostic testing of structures within a body, e.g., organs within the body of a living being, which has been provided with a radioactive imaging agent, e.g., a radiotracer, to cause the structure to produce gamma rays, associated characteristic x rays, and a continuum of Compton-scattered photons. The system includes a radiation receiving device, e.g., a hand-held probe or camera, an associated signal processor, and an analyzer. The radiation receiving device is arranged to be located adjacent the body and the structure for receiving gamma rays and characteristic x rays emitted from the structure and for providing a processed electrical signal representative thereof. The processed electrical signal includes a first portion representing the characteristic x rays received and a second portion representing the gamma rays received. In a preferred embodiment of the invention the signal processor removes the signal corresponding to the Compton-scattered photons from the electrical signal in the region of the full-energy gamma ray and the characteristic x ray. The analyzer is arranged to selectively use the x-ray portion of said processed signal to provide near-field information about the structure, to selectively use both the x-ray and the gamma-ray portions of said processed signal to provide near-field and far-field information about the structure, and to selectively use the gamma-ray portion of said processed signal to provide extended field information about the structure.

Claims

1. A system for determining the density of a mass of tissue of interest, said system comprising radiation detecting means, signal processing means and signal analyzing means, wherein the tissue of interest is intervening between the radiation detecting means and underlying tissue which has been provided with at least one radiolabelled tracer producing gamma-ray photons, characteristic x-ray photons, and an associated continuum of Compton scattered photons, said radiation detecting means being positionable to a location adjacent the intervening tissue of interest for detecting the photons emitted by said underlying radiolabelled tissue which pass a predetermined distance through the intervening tissue, said radiation detecting means providing an electrical signal representative of the received photons, said signal processing means processing said electrical signal to produce a processed electrical signal representative of the number of photons detected as a function of their energies, said processed electrical signal including a first portion representing the characteristic x-ray photons received and a second portion representing the gamma-ray photons received, said analyzing means, comprising spectral line shape analyzing means, being arranged for analyzing at least a selected one of said first and second portions of said processed signal to provide an indication of the density of the intervening tissue of interest.

2. The system of claim 1 wherein said processed signal includes at least one asymmetrical portion and wherein said spectral line shape analyzing means determines the degree of asymmetry of at least a selected one of said first and second portions of said processed signal to provide the indication of the density of the intervening tissue.

3. The system of claim 1 wherein said processed signal has a shape and wherein spectral line shape analyzing means comprising means defining plural reference shapes, at least one of said reference shapes representing at least a selected one of said first and second portions of said processed signal resulting from at least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, said spectral line shape analyzing means comparing the shape of the at least one portion of said processed signal to at least one of said plural reference shapes.

4. The system of claim 1 wherein said processor signal has a shape and wherein said spectral line shape analyzing means comprises means defining plural reference shapes, at least one of said reference shapes representing the gamma-ray portion of said processed signal resulting from at least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, and at least another of said reference shapes representing the characteristic x-ray portion of said processed signal resulting from at least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, said spectral line shape analyzing means comparing the shape of the at least one portion of said processed signal to at least one of said plural reference shapes.

5. A method for determining the density of a mass of tissue of interest, wherein the tissue of interest is intervening between an exterior or exposed tissue plane and tissue underlying the tissue plane, comprising:

a) providing the underlying tissue with a radiotracer that produces gamma-ray photons, characteristic x-ray photons, and an associated continuum of Compton-scattered photons;

b) providing radiation detecting means adjacent the tissue of interest for detecting photons emitted by said underlying radiolabelled tissue which pass a predetermined distance through intervening tissue and for providing an electrical signal representative of the received photons;

c) processing said electrical signal to produce a processed electrical signal representative of the number of photons detected as a function of their energies, said processed signal having a shape and including a first portion representing the characteristic x-ray photons received and a second portion representing the gamma-ray photons received; and

d) analyzing the spectral line shape of at least a selected one of said first and second portions of said processed signal to provide an indication of the density of the intervening tissue of interest.

6. The method of claim 5 wherein said processed signal includes at least one asymmetrical portion and wherein said step d) is accomplished by determining the degree of asymmetry of the at least a selected portion of said processed signal to provide the indication of the density of the intervening tissue.

7. The method of claim 6 additionally comprising providing data defining plural reference shapes, with at least one of said reference shapes representing at least a selected one of said first and second portions of said processed signal resulting from the least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, and wherein the shape of the at least one portion of said processed signal is compared to at least one of said plural reference shapes.

8. The method of claim 6 additionally comprising providing data defining plural reference shapes, with at least one of said reference shapes representing the gamma-ray portion of said processed signal resulting from the least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, and at least another of said reference shapes representing the characteristic x-ray portion of said processed signal resulting from the least one radiolabelled tracer after passing a predetermined distance through a predetermined type of tissue, and wherein the shape of the at least one portion of said processed signal is compared to at least one of said plural reference shapes.