Method and apparatus for non-invasive diagnosis of cardiovascular and related disorders
First Claim
1. A method for diagnosing cardiovascular related illness, said method comprising the steps of:
- (a) non-invasively obtaining a signal representative of a contour of an arterial pressure pulse over a single cardiac cycle and without disturbing the natural state of the artery;
(b) extracting frequency localization information and temporal localization information from said signal;
(c) providing the extracted information as an input to a neural network, the neural network having been trained with a plurality of training sets, each training set correlating an arterial pressure pulse contour with a known cardiovascular or related illness; and
(d) generating an illness identification output from the neural network.
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Abstract
Apparatus and method for non-invasive diagnosis of cardiovascular and related disorders. The system establishes a correspondence between the dynamics of the wave contour of the arterial pressure pulse and the associated disease states. The system comprises an input module, a contour signal receiver, and a processing module. The input module utilizes a pressure transducer for taking a non-invasive measurement of the arterial pulse. The contour signal receiver amplifies, digitizes and normalizes the arterial pressure pulse signal. In the processing module, the normalized arterial pressure contour is subjected to wavelet analysis, which transforms the dynamics of the time series of arterial blood pressure contour into multi-resolution wavelet coefficients or signatures. The processing module includes a neural network which is trained to associate the diagnostic features of the transformed arterial pressure contour embedded in the coefficients with a disease condition. After the learning phase, the system is capable of diagnosing known cardiovascular conditions in patients.
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Citations
17 Claims
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1. A method for diagnosing cardiovascular related illness, said method comprising the steps of:
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(a) non-invasively obtaining a signal representative of a contour of an arterial pressure pulse over a single cardiac cycle and without disturbing the natural state of the artery; (b) extracting frequency localization information and temporal localization information from said signal; (c) providing the extracted information as an input to a neural network, the neural network having been trained with a plurality of training sets, each training set correlating an arterial pressure pulse contour with a known cardiovascular or related illness; and (d) generating an illness identification output from the neural network. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for detecting symptoms associated with cardiovascular related illnesses in a patient said system comprising:
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input means for receiving a signal representative of a contour of an arterial pressure pulse, said signal being obtained in a non-invasive manner from the patient and over a single cardiac cycle and without disturbing the natural state of the artery; information extraction means coupled to said input means for extracting frequency localization information and temporal localization information from the signal and including means for producing a localization information output signal representing a portion of the extracted information; and a neural network training with a plurality of training sets, each training set correlating an arterial pressure pulse contour with a known cardiovascular or related illness, said neural network including means for receiving said localization information output signal and means for producing an illness identification output signal representing a correlation between the extracted information and a cardiovascular related symptom derived from said training sets. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification