Combinatorial kit for polymer synthesis
First Claim
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1. A kit for use in forming diverse polymer sequences on a substrate, comprising:
- a substrate having a surface comprising active sites thereon for the reaction of a selected reagent;
a channel block, said channel block having a first surface and a plurality of recessed regions disposed in said first surface;
one or more apertures in communication with the plurality of recessed regions;
a holder for engaging said first surface of said channel block with a surface of said substrate;
a translator, said translator moving said channel block and said substrate relative to each other; and
a reagent delivery system for injecting selected reagents into said one or more apertures.
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Abstract
A device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.
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Citations
22 Claims
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1. A kit for use in forming diverse polymer sequences on a substrate, comprising:
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a substrate having a surface comprising active sites thereon for the reaction of a selected reagent; a channel block, said channel block having a first surface and a plurality of recessed regions disposed in said first surface; one or more apertures in communication with the plurality of recessed regions; a holder for engaging said first surface of said channel block with a surface of said substrate; a translator, said translator moving said channel block and said substrate relative to each other; and a reagent delivery system for injecting selected reagents into said one or more apertures. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An apparatus for delivering fluids to a plurality of selected regions on surface of a substrate, comprising
a substrate having selected regions thereon, said selected regions having a surface comprising active sites thereon for the reaction of a selected reagent; -
a body of a channel block having a first surface, said first surface having a plurality of recessed regions disposed therein, whereby when said first surface is mated with said surface of said substrate, said plurality of recessed regions are adjacent to said selected regions on said surface of said substrate; a plurality of fluid inlets disposed in said body, each of said plurality of fluid inlets being fluidly connected to at least one of said plurality of recessed regions; and a translator, said translator moving said channel block and said substrate relative to each other. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification