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systems and methods for performing magnetic chromatography assays

  • US 6,136,549 A
  • Filed: 10/15/1999
  • Issued: 10/24/2000
  • Est. Priority Date: 10/15/1999
  • Status: Expired due to Term
First Claim
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1. A magnetic chromatography method for performing a bioassay comprising the steps:

  • a) providing a chromatographic medium;

    b) providing a magnetic field;

    c) providing a reaction mixture suspected of, containing an analyte, a reporter ligand that binds to said analyte, and a quantity of magnetic particles with capture ligands for binding said analyte immobilized thereon suspended therein;

    d) contacting said chromatographic medium with said reaction mixture such that said reaction mixture flows laterally across said chromatographic medium;

    e) applying said magnetic field at a site upon said chromatographic medium, said magnetic field being so applied such that a majority of said magnetic particles suspended within said reaction mixture is caused to become captured upon said medium at said site where said magnetic field is applied; and

    f) analyzing said majority of magnetic particle captured upon said chromatographic medium.

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