Intraoral topical anti-inflammatory treatment for relief of migraine, tension-type headache, post-traumatic headache facial pain, and cervical-muscle spasm

• US 6,139,861 A
• Filed: 08/09/1999
• Issued: 10/31/2000
• Est. Priority Date: 01/14/1999
• Status: Expired due to Term

• Current Assignee: BF Management Holdings, LLC
• Original Assignee: Mark M. Friedman
• Inventors: Friedman, Mark
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Pulliam, Amy E
• Application Number:
  US09/370,915
• Time in Patent Office: 449 Days
• Field of Search: 424/435, 424/434, 424/443, 424/489
• US Class Current: 424/435
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/57 substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
• CPC Class Codes: A61K 31/573 substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61K 31/58 containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin digitoxin A61K31/7048
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 31/616 by carboxylic acids, e.g. acetylsalicylic acid
• CPC Class Codes: A61K 9/006 Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
• CPC Class Codes: A61K 9/0063 Periodont

Abstract

An anti-inflammatory, either a NSAID or glucocorticoid steroid in the form of an ointment, cream, lotion, gel, powder, paste, film, tape or adhesive bandage, provided with appropriate vehicle to allow specific adherence to a specific gingival area is applied to the area of maxillary alveolar tenderness located in the maxillary third molar apical area. This intraoral area of tenderness is noted consistently in a number of painful conditions and can be used in this manner including to prevent or relieve migraine, tension-type headache, post-traumatic headache, facial pain and cervical muscle spasm.

Claims

1. Method of treating migraine, tension type headache, post-traumatic headache, facial pain and cervical muscle spasm, associated with a zone of intraoral inflammation localized in the maxillary third molar apical area which comprises topically applying directly to the mucous membrane of the mouth in the maxillary third molar apical area correlating to the plexus formed by the posterior superior alveolar branch of the ipsilateral maxillary nerve, at least one anti-inflammatory medicine selected from the group consisting of non-steroid anti inflammatory drugs (NSAID) and glucocorticoid steroids in a pharmaceutically effective form and amount.

2. Method according to claim 1 wherein said pharmaceutically effective form is selected from the group consisting of ointments, creams, lotions, gels, powders, tablets, pastes, films, tapes and adhesive bandages.

3. Method according to claim 1 wherein said anti-inflammatory medication is a non-steroid anti-inflammatory drug (NSAID).

4. Method according to claim 3 wherein said non-steroid anti-inflammatory drug is used in combination with a glucocorticoid steroid.

5. Method according to claim 3 wherein said non-steroid anti-inflammatory drug is a member selected from the group consisting of aspirin, acetaminophen, Ibuprofen, Tylenol, Naproxen, Ketoprofen and mixtures thereof.

6. Method according to claim 5 wherein said non-steroid anti-inflammatory drug is Ketoprofen.

7. Method according to claim 4 wherein said glucocorticoid steroid is a member selected from the group consisting of cortisone, hydrocortisone, prednisolone, prednisolone, triamcinolone, clobetasol propionate, fluocinonide and fluocinolone.

8. Method according to claim 7 wherein said glucocorticoid steroid is triamcinolone.

9. Method according to claim 4 wherein said non-steroid anti-inflammatory drug is aspirin and said glucocorticoid steroid is triamcinolone.

10. Method according to claim 1 wherein said pharmaceutically effective form is selected from the group consisting of ointments, creams, lotions, gels and pastes and iontophoresis is used to deliver said medication beneath the mucous membrane to said area of inflammation.