Method and apparatus to allow cyclic pacing at an average rate just above the intrinsic heart rate so as to maximize inotropic pacing effects at minimal heart rates

• US 6,141,586 A
• Filed: 05/26/1998
• Issued: 10/31/2000
• Est. Priority Date: 08/19/1996
• Status: Expired due to Term

• Current Assignee: MR3 Medical, LLC
• Original Assignee: Mower Family Chf Treatment Irrevocable Trust
• Inventors: Mower, Morton M.
• Primary Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US09/084,571
• Time in Patent Office: 889 Days
• Field of Search: 607/9, 607/14, 607/15, 607/122
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36592 controlled by the heart rate variability
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

Method and apparatus for cyclic ventricular pacing starting at a rate just above the intrinsic atrial firing rate (overdrive pacing), followed by relaxation to a rate just below the intrinsic atrial firing rate (ventricular escape). The method and apparatus can be applied to one or both ventricles, and can utilize one or more electrodes per ventricle. The electrode(s) can be applied to inner or outer ventricular surfaces. Relaxation protocols as a function of time can be linear, curvilinear to include exponential, or mixtures thereof. Furthermore, relaxation protocols can include one or more periods of time during which the pacing rate is held constant. Typically, the average ventricular pacing rate using this invention will be slightly greater than the intrinsic atrial firing rate, though alternate embodiments that encompass average ventricular pacing rates that are equal to or slightly less than the intrinsic atrial firing rate are also envisioned. Application of this method and apparatus to a heart in need thereof will produce a heart with an optimally minimized energy output requirement.

Claims

1. A method for cardiac pacing for a heart having an intrinsic atrial firing rate, comprising:

applying a series of pacing stimuli to at least one ventricle having an initial pacing rate, where the initial pacing rate is slightly greater than the intrinsic atrial firing rate; and

decreasing the pacing rate over time from the initial pacing rate to a minimum pacing rate that is slightly less than the intrinsic atrial firing rate.

2. The method for cardiac pacing according to claim 1, further comprising sensing physiological parameters to determine if additional cardiac pacing is needed.

3. The method for cardiac pacing according to claim 2, where the physiological parameters are selected from the group consisting of A-V interval, atrial entrainment of left and right ventricles, length of QRS complex, magnitude of QRS complex, arterial blood pressure, venous blood pressure, heart rate, ventricular fibrillation, atrial fibrillation, and probability density function.

4. The method for cardiac pacing according to claim 1, where applying the pacing stimuli and decreasing the pacing rate is repeated in a cyclic pattern.

5. The method for cardiac pacing according to claim 1, where a protocol for decreasing the pacing rate over time is selected from the group consisting of linear, curvilinear, exponential, and combinations thereof.

6. The method for cardiac pacing according to claim 5, where the protocol for decreasing the pacing rate includes one or more periods of time in which the pacing rate is held constant.

7. The method for cardiac pacing according to claim 1, where a protocol for decreasing the pacing rate includes one or more periods of time in which the pacing rate is held constant.

8. The method for cardiac pacing according to claim 1, where the initial pacing rate minus the intrinsic atrial firing rate is greater than the intrinsic atrial firing rate minus the minimum pacing rate.

9. The method for cardiac pacing according to claim 1, where the initial pacing rate minus the intrinsic atrial firing rate is equal to the intrinsic atrial firing rate minus the minimum pacing rate.

10. The method for cardiac pacing according to claim 1, where the initial pacing rate minus the intrinsic atrial firing rate is less than the intrinsic atrial firing rate minus the minimum pacing rate.

11. The method for cardiac pacing according to claim 1, where the pacing stimuli are selected from the group consisting of monophasic stimulation and biphasic stimulation.

12. The method for cardiac pacing according to claim 11, where the monophasic stimulation is selected from the group consisting of cathodal stimulation and anodal stimulation.

13. The method for cardiac pacing according to claim 11, where the biphasic stimulation comprises an anodal stimulation phase followed by a cathodal stimulation phase.

14. The method for cardiac pacing according to claim 13, where the anodal stimulation phase:

has a magnitude equal to or less than a maximum subthreshold amplitude; and

has an approximate shape selected from the group consisting of square wave, increasing ramp, and series of short duration square waves.

15. The method for cardiac pacing according to claim 1, where the pacing stimuli are applied via multiple electrodes to at least one ventricle.

16. A method for cardiac pacing for a heart with a paced atrial firing rate, comprising:

applying a series of pacing stimuli to at least one ventricle, where the initial ventricular pacing rate is slightly greater than the paced atrial firing rate; and

decreasing the initial ventricular pacing rate over time to a minimum pacing rate that is slightly less than the paced atrial firing rate.

17. The method for cardiac pacing according to claim 16, wherein applying the pacing stimuli and decreasing the pacing rate is repeated in a cyclic pattern.

18. The method for cardiac pacing according to claim 16, where a protocol for decreasing the initial ventricular pacing rate over time is selected from the group consisting of linear, curvilinear, exponential, and combinations thereof.

19. The method for cardiac pacing according to claim 18, where the protocol for decreasing the initial pacing rate includes one or more periods of time in which the pacing rate is held constant.

20. The method for cardiac pacing according to claim 16, where a protocol for decreasing the pacing rate includes one or more periods of time in which the pacing rate is held constant.

21. The method for cardiac pacing according to claim 16, where the initial ventricular pacing rate minus the paced atrial firing rate is greater than the paced atrial firing rate minus the minimum ventricular pacing rate.

22. The method for cardiac pacing according to claim 16, where the initial ventricular pacing rate minus the paced atrial firing rate is equal to the paced atrial firing rate minus the minimum ventricular pacing rate.

23. The method for cardiac pacing according to claim 16, where the initial ventricular pacing rate minus the paced atrial firing rate is less than the paced atrial firing rate minus the minimum ventricular pacing rate.

24. The method for cardiac pacing according to claim 16, where the pacing stimuli are selected from the group consisting of monophasic stimulation and biphasic stimulation.

25. The method for cardiac pacing according to claim 24, where the monophasic stimulation is selected from the group consisting of cathodal stimulation and anodal stimulation.

26. The method for cardiac pacing according to claim 24, where the biphasic stimulation comprises an anodal stimulation phase followed by a cathodal stimulation phase.

27. The method for cardiac pacing according to claim 26, where the anodal stimulation phase:

has a magnitude equal to or less than a maximum subthreshold amplitude; and

has an approximate shape selected from the group consisting of square wave, increasing ramp, and series of short duration square waves.

28. The method for cardiac pacing according to claim 16, where the pacing stimuli are applied via multiple electrodes to at least one ventricle.