System and method for respiration-modulated pacing

• US 6,141,590 A
• Filed: 09/25/1997
• Issued: 10/31/2000
• Est. Priority Date: 09/25/1997
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Renirie, Alexis C. M., Schouten, Vincent J. A.
• Primary Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/937,443
• Time in Patent Office: 1,132 Days
• Field of Search: 607/9, 607/17, 607/20, 607/23, 607/24, 607/18, 607/19
• US Class Current: 607/20
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A system and method of providing for cardiac pacing which incorporates modulation of the pacing rate in order to minimize variations in ventricular power output, e.g., variation related to patient respiratory phases. In a preferred embodiment, pacing rate is increased during inspiration relative to expiration, to restore a measure of the normal rate modulation which occurs in a normal person. Patient respiration is monitored and a respiration signal is processed to determine the timing of rate modulation. Parameters representative of respiratory changes, such as right ventricular volume and right ventricular blood pressure are also monitored and, together with respiration amplitudes changes, are used to determine an incremental rate signal for controlling the extent of rate variation. Heart rate and patient activity are also sensed, to provide further control of rate modulation, with maximum modulation being provided when the patient is sleeping, and minimal or no modulation being provided when the patient is active. The system of this invention is applicable in combination with conventional pacing systems, or can be adapted to special clinical applications.

Claims

1. A system for respiration modulated pacing, comprising:

pulse generator means for generating and delivering pacing pulses to one of a vagus nerve and sympathetic nerve system to control the beat rate of a patient'"'"'s heart; and

rate control means for controlling a pacing rate of said pacing pulses, said rate control means further comprising;

respiration means for obtaining respiration signals representative of patient respiration, and modulation means for developing rate modulation signals for controlling said pacing rate to change as a function of said respiration signals and to increase during the patient'"'"'s inspiration phase relative to the pacing rate during the patients expiration phase.

2. The system as described in claim 1, wherein said respiration means comprises sensing means for sensing signals representative of the patient'"'"'s intrathoracic pressure.

3. The system as described in claim 1, wherein said respiration means comprises signal means for providing a signal indicating the onset of patient inspiration, and said modulation means comprises timing means for timing rate modulation signals to increase pacing rate in response to a said indicated inspiration onset.

4. The system as described in claim 3, wherein said timing means comprises delay means for delaying the increase in pacing rate following a said indicated inspiration onset.

5. The system as described in claim 1, wherein said modulation means comprises amplitude means for controlling an amplitude of pacing rate change and timing means for controlling the timing of said pacing rate change relative to the patient'"'"'s Inspiration phase and expiration phase of said patient'"'"'s respiratory cycle.

6. The system as described in claim 5, wherein said amplitude means comprises cardiac work means for determining a measure of cyclical cardiac work and for controlling said amplitude as a function of said work measure.

7. The system as described in claim 5, wherein said amplitude means comprises volume means for determining a measure of the end-diastolic volume of a ventricle of said patient and for controlling said amplitude as a function of said volume measure.

8. The system as described in claim 5, wherein said amplitude means comprises pressure means for determining a measure of the blood pressure relating to a ventricle of said patient and for controlling said amplitude as a function of said blood pressure measure.

9. The system as described in claim 5, wherein said amplitude means comprises maximum rate change means for limiting the amplitude of pacing rate change during said respiratory cycle.

10. The system as described in claim 9, wherein said maximum rate change means comprises body position sensor means for sensing the patient'"'"'s body position and for limiting said amplitude of pacing rate change as a function of said sensed body position.

11. The system as described in claim 9, wherein said maximum rate change means comprises heart rate means for determining a measure of the patient'"'"'s heart rate and for limiting said amplitude of pacing rate change as a function of said heart rate measure.

12. The system as described in claim 5, wherein said respiration means comprises means for determining the onset of patient inspiration, and said timing means comprises means for enabling said modulation means to increase said pacing rate in response to a said indicated inspiration onset.

13. The system as described in claim 12, wherein said timing means comprises delay means for delaying enablement of said modulation means relative to said inspiration onset.

14. The system as described in claim 1, further comprising means for determining a measure of patient activity, and inhibit means for inhibiting said modulation means from changing said pacing rate as a function of respiration signals when said activity measure exceeds a predetermined reference level.

15. A system for pacing a patient'"'"'s heart, comprising:

pulse generator means for generating and delivering pace pulses to one of a vagus nerve and sympathetic nerve system of said patient;

rate control means for controlling a pacing rate at which said pulse generator means generates and delivers pace pulses;

respiration means for obtaining respiration signals representative of patient'"'"'s respiration, and

said rate control means comprising modulation means for modulating said pacing rate as a function of said respiration signals.

16. The system as described in claim 15, wherein said respiration means comprises means for determining patient inspiration and expiration, and said modulation means comprises means for increasing said pacing rate during inspiration relative to pacing rate during expiration.

17. The system as described in claim 15, wherein said respiration means comprises means for obtaining signals representative of patient inspiration, and said modulation means comprises means for increasing said pacing rate in response to said signals representative of patient inspiration.

18. The system as described in claim 17, further comprising rate means for detecting patient sinus rate, and wherein said modulation means comprises means for overdriving said sinus rate during periods of patient inspiration.

19. The system as described in claim 15, further comprising power means for determining a measure of cardiac power output, and wherein said modulation means further comprises means for adjusting pacing rate as a function of said cardiac power output measure.

20. The system as described in claim 15, further comprising activity means for obtaining activity representations of patient activity or position, and wherein said modulation means further comprises means for adjusting pacing rate as a function of said activity representations.

21. The system as described in claim 15, further comprising pressure means for obtaining pressure representations of the patient'"'"'s ventricular pressure, and wherein said modulation means further comprises means for adjusting pacing rate as a function of said pressure representations.

22. The system as described in claim 15, further comprising volume means for obtaining volume representations of the patient'"'"'s ventricular volume, and wherein said modulation means further comprises means for adjusting pacing rate as a function of said volume representations.

23. An implantable system for varying a patient'"'"'s heart rate as a function of the patient'"'"'s respiratory cycles, comprising:

a stimulus generator for generating stimulus signals at a rate;

delivery means for delivering said stimulus signals to one of a vagus nerve and sympathetic nerve system within said patient and to modulate the patient'"'"'s heart rate;

respiration means for obtaining respiration signals representative of the patient'"'"'s respiratory cycles; and

control means for controlling said stimulus generator to generate said stimulus signals as a function of said respiration signals.

24. The system as described in claim 23, wherein said respiration means comprises means for determining periods of patient expiration, and said control means has means for controlling said stimulus generator to generate stimulus signals during an expiration period.

25. The system as described in claim 23, wherein said respiration means comprises means for determining periods of patient inspiration, and said control means comprises means for increasing the rate of said stimulus signals during periods of inspiration.

26. A method of pacing a patient to provide a respiration-modulated heart rate, comprising:

obtaining respiration signals representative of the inspiratory and expiratory phases of the patient'"'"'s respiratory cycle,

generating phasic rate control signals as a function of at least one of said inspiratory and expiratory phases,

generating stimulus pulses at a rate controlled by said phasic rate control signals, and

delivering said phasic rate controlled stimulus pulses to one of the vagus nerve and sympathetic nerve system to pace the patient'"'"'s heart at a relatively higher rate during said inspiratory phase compared to said expiratory phase.

27. The method of pacing as described in claim 26, further comprising the steps of obtaining volume signals representative of the patient'"'"'s right ventricular volume, and generating said phasic rate control signals as a function of said volume signals.

28. The method of pacing as described in claim 26, further comprising the steps of obtaining pressure signals representative of the patient'"'"'s right ventricular blood pressure, and generating said phasic rate control signals as a function of said pressure signals.