Inhalation device

• US 6,142,146 A
• Filed: 06/12/1998
• Issued: 11/07/2000
• Est. Priority Date: 06/12/1998
• Status: Expired due to Term

• Current Assignee: MicroDose Therapeutx, Inc. (Teva Pharmaceutical Industries Limited)
• Original Assignee: Microdose Technologies Inc. (Teva Pharmaceutical Industries, Ltd.)
• Inventors: Gumaste, Anand V., Abrams, Andrew L.
• Primary Examiner(s): Lewis, Aaron J.
• Application Number:
  US09/097,105
• Time in Patent Office: 879 Days
• Field of Search: 128/200.16, 128/203.15, 128/203.21, 128/200.14, 604/58
• US Class Current: 128/203.15
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/0081 Locking means
• CPC Class Codes: A61M 15/0083 Timers
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/02 with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/50 with microprocessors or computers

Abstract

A dry powder inhaler comprises a first chamber in which a dry powder may be deaggregated by a vibrator and separated by size, and a second chamber in which the size-separated deaggregated powder may be picked up by an air stream and carried for introduction into a patient. Electronic circuitry is included for controlling dosing.

Claims

1. In a dry powder inhaler comprising a first chamber, a vibrator operatively connected to said first chamber in which a dry powder is deaggregated by said vibrator and separated by size, and a second chamber in which the size-separated deaggregated powder is picked up by an air stream generated during inhalation by a patient through an opening in said inhaler and is carried for introduction into the patient, the improvement which comprises electronic circuitry with feedback control for controlling dosing.

2. In a dry powder inhaler according to claim 1, wherein said electronic circuitry includes a microprocessor controller for controlling dosing according to a pre-determined delivery protocol.

3. In a dry powder inhaler according to claim 1, the improvement wherein said electronic circuitry includes a microprocessor controller for controlling the quantity of said powder delivered over time.

4. In a dry powder inhaler according to claim 3, wherein the quantity of said powder delivered over time is varied with time.

5. In a dry powder inhaler according to claim 1, in which said electronic circuitry counts doses delivered.

6. In a dry powder inhaler according to claim 1, in which said electronic circuitry monitors patient compliance.

7. In a dry powder inhaler according to claim 6, and further including means for recording patient usage, and for downloading the resulting record to a remote reader.

8. In a dry powder inhaler according to claim 1, wherein said electronic circuitry includes a clock.

9. In a dry powder inhaler according to claim 8, and furthermore including means associated with said clock for reminding a patient.

10. In a dry powder inhaler according to claim 9, wherein said means for reminding comprises a tone generator.

11. In a dry powder inhaler according to claim 8, and further comprising a lockout device associated with said clock for limiting frequency of use of said inhaler.

12. In a dry powder inhaler according to claim 1, and further comprising a lockout device for preventing unauthorized use of said inhaler.

13. In a dry powder inhaler according to claim 1, and further comprising an environmental sensor associated with said electronic circuitry for deactivating the inhaler in the event the inhaler is exposed to ambient temperature conditions outside a predetermined range.

14. In a dry powder inhaler according to claim 13, and further comprising a display warning activated by said environmental sensor when said inhaler is exposed to ambient temperature conditions outside said predetermined range.

15. In a dry powder inhaler according to claim 1, further comprising a clock and lockout device for deactivating said inhaler at the expiration of a predetermined shelf life.

16. In a dry powder inhaler according to claim 1, wherein said electronic circuitry includes a controller for controlling operation of said vibrator over a plurality of frequencies.

17. In a dry powder inhaler according to claim 1, wherein said electronic circuitry comprises a microprocessor.

18. In a dry powder inhaler according to claim 1, wherein said electronic circuitry comprises a custom integrated circuit.

19. In a dry powder inhaler according to claim 1, wherein said electronic circuitry comprises discrete electrical and electronic components.

20. In a dry powder inhaler comprising a first chamber, a vibrator operatively connected to said first chamber in which a dry powder is deaggregated by said vibrator and separated by size, and a second chamber in which the size-separated deaggregated powder is picked up by an air stream generated during inhalation by a patient through an opening in said inhaler and is carried for introduction into the patient, the improvement wherein said first chamber contains two or more vibrators designed to vibrate at different frequencies.

21. In a dry powder inhaler comprising a first chamber, a vibrator operatively connected to said first chamber in which a dry powder is deaggregated by said vibrator and separated by size, and a second chamber in which the size-separated deaggregated powder is picked up by an air stream generated during inhalation by a patient through an opening in said inhaler and is carried for introduction into the patient, the improvement which comprises electronic circuitry for controlling dosing, and an environmental sensor associated with said electronic circuitry, for deactivating the inhaler in the event the inhaler is exposed to ambient temperature conditions outside of a predetermined range.

22. In a dry powder inhaler according to claim 21, wherein said electronic circuitry includes a microprocessor controller for controlling dosing according to a pre-determined delivery protocol.

23. In a dry powder inhaler according to claim 21, the improvement wherein said electronic circuitry includes a microprocessor controller for controlling the quantity of said powder delivered over time.

24. In a dry powder inhaler according to claim 23, wherein the quantity of said powder delivered over time is varied with time.

25. In a dry powder inhaler according to claim 21, in which said electronic circuitry counts doses delivered.

26. In a dry powder inhaler according to claim 21, in which said electronic circuitry monitors patient compliance.

27. In a dry powder inhaler according to claim 26, and further including means for recording patient usage, and for downloading the resulting record to a remote reader.

28. In a dry powder inhaler according to claim 21, wherein said electronic circuitry includes a clock.

29. In a dry powder inhaler according to claim 28, and furthermore including means associated with said clock for reminding a patient.

30. In a dry powder inhaler according to claim 29, wherein said means for reminding comprises a tone generator.

31. In a dry powder inhaler according to claim 28, and further comprising a lockout device associated with said clock for limiting frequency of use of said inhaler.

32. In a dry powder inhaler according to claim 21, and further comprising a lockout device for preventing unauthorized use of said inhaler.

33. In a dry powder inhaler according to claim 21, and further comprising a display warning activated by said environmental sensor when said inhaler is exposed to ambient temperature conditions outside said predetermined range.

34. In a dry powder inhaler according to claim 21, further comprising a clock and lockout device for deactivating said inhaler at the expiration of a predetermined shelf life.

35. In a dry powder inhaler according to claim 21, wherein said electronic circuitry includes a controller for controlling operation of said vibrator over a plurality of frequencies.

36. In a dry powder inhaler according to claim 21, wherein said electronic circuitry comprises a microprocessor.

37. In a dry powder inhaler according to claim 21, wherein said electronic circuitry comprises a custom integrated circuit.

38. In a dry powder inhaler according to claim 21, wherein said electronic circuitry comprises discrete electrical and electronic components.

39. In a dry powder inhaler comprising a first chamber, a vibrator operatively connected to said first chamber in which a dry powder is deaggregated by said vibrator and separated by size, and a second chamber in which the size-separated deaggregated powder is picked up by an air stream generated during inhalation by a patient through an opening in said inhaler and is carried for introduction into the patient, the improvement which comprises electronic circuitry for controlling dosing, said electronic circuitry including a controller for controlling operation of said vibrator over a plurality of frequencies.

40. In a dry powder inhaler according to claim 39, wherein said electronic circuitry includes a microprocessor controller for controlling dosing according to a pre-determined delivery protocol.

41. In a dry powder inhaler according to claim 39, the improvement wherein said electronic circuitry includes a microprocessor controller for controlling the quantity of said powder delivered over time.

42. In a dry powder inhaler according to claim 41, wherein the quantity of said powder delivered over time is varied with time.

43. In a dry powder inhaler according to claim 39, in which said electronic circuitry counts doses delivered.

44. In a dry powder inhaler according to claim 39, in which said electronic circuitry monitors patient compliance.

45. In a dry powder inhaler according to claim 44, and further including means for recording patient usage, and for downloading the resulting record to a remote reader.

46. In a dry powder inhaler according to claim 39, wherein said electronic circuitry includes a clock.

47. In a dry powder inhaler according to claim 46, and furthermore including means associated with said clock for reminding a patient.

48. In a dry powder inhaler according to claim 47, wherein said means for reminding comprises a tone generator.

49. In a dry powder inhaler according to claim 46, and further comprising a lockout device associated with said clock for limiting frequency of use of said inhaler.

50. In a dry powder inhaler according to claim 39, and further comprising a lockout device for preventing unauthorized use of said inhaler.

51. In a dry powder inhaler according to claim 39, further comprising a clock and lockout device for deactivating said inhaler at the expiration of a predetermined shelf life.

52. In a dry powder inhaler according to claim 39, wherein said electronic circuitry comprises a microprocessor.

53. In a dry powder inhaler according to claim 39, wherein said electronic circuitry comprises a custom integrated circuit.

54. In a dry powder inhaler according to claim 39, wherein said electronic circuitry comprises discrete electrical and electronic components.