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Microporation of human skin for drug delivery and monitoring applications

  • US 6,142,939 A
  • Filed: 12/09/1998
  • Issued: 11/07/2000
  • Est. Priority Date: 11/15/1993
  • Status: Expired due to Term
First Claim
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1. An apparatus for forming micropores in a selected area of the stratum corneum for enhancing the permeability of the skin, the apparatus comprising a heat conducting element to be placed in substantial physical contact with the selected area to deliver sufficient energy by conduction to said selected area such that the temperature of tissue-bound water and other vaporizable substances in said selected area is elevated above the vaporization point of said water and other vaporizable substances thereby removing the stratum corneum and forming at least one micropore 1-1000 μ

  • m across in said selected area of said stratum corneum.

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