Method and apparatus for detection and diagnosis of airway obstruction degree

• US 6,142,952 A
• Filed: 10/29/1997
• Issued: 11/07/2000
• Est. Priority Date: 10/29/1997
• Status: Expired due to Term

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Behbehani, Khosrow, Lucas, Edgar R., Burk, John R., Yen, Fu-Chung
• Primary Examiner(s): Leubecker, John P.
• Assistant Examiner(s): GIBSON, ROY DEAN
• Application Number:
  US08/959,938
• Time in Patent Office: 1,105 Days
• Field of Search: 600/529, 600/531-535, 600/481, 600/483, 600/484
• US Class Current: 600/533
• CPC Class Codes: A61B 5/085 Measuring impedance of respiratory organs or lung elasticity
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7253 characterised by using transforms
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

A pressurized breathable gas, preferably air, is supplied to the patient'"'"'s airways with an interface including a mask and a flexible hose. A selected oscillation component or forced probing signal is applied or superposed on the pressurized breathable gas, preferably with a loudspeaker coupled to a frequency generator. Pressure and flow of the breathable gas in the interface are measured or sampled, preferably using pressure transducers and a pneumotachometer coupled to a personal computer, to obtain pressure and flow data characteristic of the patient'"'"'s airway. The pressure and flow data are converted to the frequency domain using Fourier transform or cross-power spectrum techniques in the personal computer. A function of the processed pressure and flow data is obtained to determine an index of airway impedance or degree of airway obstruction.

Claims

1. A method of determining the airway impedance of a patient comprising the steps of:

supplying breathable gas to the patient'"'"'s airways with an interface;

applying a selected audio-frequency oscillation component to a pressure of the breathable gas;

measuring pressure and flow of the breathable gas in the interface to obtain pressure and flow data characteristic of the patient'"'"'s airway;

converting the pressure and flow data to the frequency domain; and

obtaining a mathematical function of the processed pressure and flow data to determine an index of airway impedance or degree of airway obstruction.

2. The method according to claim 1 further comprising processing the measured pressure and flow data to eliminate data having indicia of unreliability after converting it to the frequency domain.

3. The method according to claim 1 wherein the step of converting the measured pressure and flow data to the frequency domain further comprises the step of:

applying a Fourier transform to the measured pressure and flow data.

4. The method according to claim 1 wherein the oscillation is a multifrequency oscillation applied by a frequency generator and loudspeaker.

5. The method according to claim 1, wherein the step of obtaining the mathematical function comprises the steps of:

dividing the pressure data by the corresponding flow data to obtain an airway impedance or degree of airway obstruction value; and

obtaining a mean impedance or degree of airway obstruction from the airway impedance or degree of airway obstruction values.

6. The method according to claim 2 wherein the processing step comprises:

discarding noisy pressure and flow data resulting from a blower supplying breathable gas to the patient'"'"'s airways through the interface; and

applying a coherence function to the pressure and flow data and discarding data with coherence less than a selected threshold.

7. A method of determining the airway impedance or degree of airway obstruction of a patient comprising the steps of:

supplying breathable gas to the patient'"'"'s airways with an interface;

applying a selected audio-frequency oscillation component to a pressure of the breathable gas;

sampling pressure and flow of the breathable gas in the interface to obtain pressure and flow data characteristic of the patient'"'"'s airway;

converting the sampled pressure and flow data to the frequency domain;

processing the converted pressure and flow data to eliminate data having indicia of unreliability; and

obtaining a mathematical function of the processed pressure and flow data to determine an index of airway impedance or degree of airway obstruction.

8. The method according to claim 7 wherein the step of converting the measured pressure and flow data to the frequency domain further comprises the step of:

applying a Fourier transform to the sampled pressure and flow data prior to, processing the pressure and flow data.

9. The method according to claim 7 wherein the oscillation is a multifrequency oscillation applied by a frequency generator and loudspeaker.

10. The method according to claim 7, wherein the step of obtaining the mathematical function comprises the steps of:

dividing processed pressure data by corresponding processed flow data to obtain an airway impedance or degree of airway obstruction value; and

obtaining a mean impedance or degree of airway obstruction from the airway impedance or degree of airway obstruction values.

11. The method according to claim 7 wherein the processing step comprises:

discarding noisy pressure and flow data resulting from a blower supplying breathable gas to the patient'"'"'s airways through the interface; and

applying a coherence function to the pressure and flow data and discarding data with coherence less than a selected threshold.

12. A method of determining the airway impedance or degree of airway obstruction of a patient comprising the steps of:

supplying breathable gas to the patient'"'"'s airways with an interface;

applying a selected audio frequency oscillation component of a selected frequency to the breathable gas;

measuring pressure and flow of the breathable gas in the interface to obtain pressure and flow data characteristic of the patient'"'"'s airway;

converting the pressure and flow data to the frequency domain;

discarding converted pressure and flow data that have indicia of inaccuracy; and

dividing the pressure data by the corresponding flow data to obtain an airway impedance or degree of airway obstruction value; and

obtaining a mean impedance or degree of airway obstruction from the airway impedance or degree of airway obstruction values.

13. The method according to claim 12 wherein the step of converting the measured pressure and flow data to the frequency domain further comprises the step of:

applying a Fourier transform to the measured pressure and flow data prior to processing the pressure and flow data.

14. The method according to claim 12 wherein the oscillation is a multifrequency oscillation applied by a frequency generator and loudspeaker.

15. The method according to claim 12 wherein the discarding step comprises:

discarding noisy pressure and flow data resulting from a blower supplying breathable gas to the patients airways through the interface; and

applying a coherence function to the pressure and flow data and discarding data with coherence less than a selected threshold.

16. An apparatus for determining the airway impedance or degree of airway obstruction of a patient comprising:

an interface adapted to be coupled to the patient'"'"'s airways to supply a breathable gas;

means for applying a selected audio-frequency oscillation component to a pressure of the breathable gas;

at least one sensor in the interface to measure pressure and flow of the breathable gas in the interface and obtain pressure and flow data characteristic of the patient'"'"'s airway; and

a processor coupled to the sensor to convert the pressure and flow data to the frequency domain and to obtain a mathematical function of the processed pressure and flow data to determine an index of airway impedance or degree of airway obstruction.