Method and device for thermally obliterating biological tissue

• US 6,143,018 A
• Filed: 03/28/1996
• Issued: 11/07/2000
• Est. Priority Date: 05/14/1993
• Status: Expired due to Fees

• Current Assignee: Huttinger Medizintechnik GmbH & Company KG, Laser-Und Medizin-Technologie Gmbh Berlin, Ceramoptec GmbH (Wolfgang Neuberger, PhD, MBA)
• Original Assignee: Huttinger GmbH, Ceramoptec GmbH (Wolfgang Neuberger, PhD, MBA)
• Inventors: Roggan, Andre, Muller, Gerhard, Beuthan, Jurgen
• Primary Examiner(s): Shay, David M.
• Application Number:
  US08/545,864
• Time in Patent Office: 1,685 Days
• Field of Search: 606/2-19, 607/88, 607/89, 607/92, 604/20
• US Class Current: 607/88
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 18/28 for heating a thermal probe or absorber
• CPC Class Codes: A61B 2018/206 the laser light passing along a liquid-filled conduit
• CPC Class Codes: A61B 2018/2261 with scattering, diffusion or dispersion of light
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/067 using laser light

Abstract

A process is disclosed for thermally obliterating biological tissues by laser radiation introduced into the tissue by means of an optical waveguide. The laser radiation is scattered by means associated with the radiation output surface of the optical waveguide. A biocompatible, medium to highly visquous liquid which does not substantially absorb the laser radiation but scatters it, is injected into the tissue, forming a scattering fluid deposit around the radiation output surface which is not separated from the tissue and which allows the tissue to be heated in a controlled manner.

Claims

1. A process for thermally obliterating biological tissue by means of laser radiation transmission through a light waveguide, comprising the steps of

introducing a light waveguide'"'"'s distal end into a biological tissue through a multichannel hollow needle and apparatus;

injecting a biocompatible fluid, having a selected viscosity, into said tissue near said distal end, wherein said fluid essentially scatters said laser radiation but does not absorb said laser radiation;

creating a deposit of said scattering fluid surrounding said lightguide'"'"'s distal end which functions as an exit surface of said laser radiation;

creating said scattering fluid deposit substantially from two components, an essentially transparent component and a highly light-scattering component, wherein said components are injected into said tissue through separate channels within a concentric double channel hollow needle such that said transparent component is injected through an inner channel and said highly light-scattering component is injected through a concentric outer channel enveloping said transparent component,

wherein said viscosity of said scattering fluid has been selected to diffuse said scattering fluid within said tissue to be thermally obliterated prior to and during laser irradiation in such a way that said scattering fluid deposit maintains a stable structure for the duration of treatment; and

transmitting said laser radiation through said waveguide and into said scattering fluid within said biological tissue to coagulate and to cause necrosis of said tissue.

2. A process according to claim 1 having the additional steps of

forming said scattering fluid from a mixture of oil, water and glycerin;

and

adjusting said mixture to contain 0.1 to 0.2% oil, 10 to 50% water and 50 to 80% glycerin depending on said tissue to be obliterated and required scattering properties for said fluid.

3. A process according to claim 1, shaving the additional steps of:

forming said scattering fluid from a mixture of methyl cellulose and water; and

adjusting said mixture'"'"'s components to contain 70 to 99% methyl cellulose and 1 to 30% water depending on required viscosity and scattering properties for said fluid.

4. A process according to claim 1, having the additional steps of:

forming said transparent component of said fluid from a mixture of glycerin and water, preferably in a ratio of 80;

20; and

forming said highly light-scattering component from a mixture of oil and water, preferably with 1 to 5% oil.

5. A process according to claim 1, wherein said fluid contains hyaluronic acid and/or Intralipid.

6. A process according to claim 1, shaving the additional step of:

after injecting and forming said scattering fluid deposit, displacing said light waveguide in said distal end'"'"'s direction so that said lightguide enters said scattering fluid deposit by a preselected amount dependent on said tissue area to obliterated.

7. A process according to claim 1, wherein creating said scattering fluid deposit is performed so as not make said deposit spherically symmetrical but rather a longitudinally-extended shape, such as an essentially ellipsoidal or cylindrical shape.

8. A process according to claim 1, having the additional step of:

monitoring temperature created in said tissue to be obliterated and its surroundings and said temperature'"'"'s propagation throughout a therapy area by means of a sonographic device, wherein echoes occur in blood vessels adjacent to said therapy area depending on said temperature;

at temperature values above 55°

C. echoes arise from previously dissolved CO₂ being expelled intermediately and at temperatures above 95°

C. echoes arise by formation of water vapor bubbles appearing intermediately within said aqueous component of said scattering fluid.

9. A process according to claim 1, having the additional steps of:

adding an X-ray contrast medium to said scattering fluid; and

monitoring progress of said process by radiological observations.

10. A process according to claim 1, wherein said transmitting of laser radiation to said biological tissue is carried out by using said transparent component of said fluid within said inner channel as a light waveguide.

11. A process according to claim 10, wherein said transmitting of laser radiation and said injecting of said transparent component of said fluid into said inner channel occur in at least overlapping time periods.