Assembled scaffolds for three dimensional cell culturing and tissue generation
DCFirst Claim
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1. A three dimensional multilayer scaffold for supporting cell growth comprising:
- a first layer for supporting cell growth; and
a second layer for supporting cell growth, said first and second layers being mechanically fastened together.
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Abstract
A three-dimensional scaffold for tissue generation. Mechanical fasteners allow layered and volumetric scaffold sections, which may be pre-seeded with cells and/or growth factors, to be assembled into a heterogeneous generated tissue for implantation.
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Citations
19 Claims
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1. A three dimensional multilayer scaffold for supporting cell growth comprising:
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a first layer for supporting cell growth; and a second layer for supporting cell growth, said first and second layers being mechanically fastened together. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of forming a three dimensional multilayer scaffold comprising:
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seeding a first prefabricated element with a component selected from the group consisting of living cells, bone marrow cells, osteoblasts, mesenchymal stem cells, satellite cells, fibroblasts, and growth factors; seeding a second prefabricated element with a component selected from the group consisting of living cells, bone marrow cells, osteoblasts, mesenchymal stem cells, satellite cells, fibroblasts, and growth factors; and connecting said first and second prefabricated elements together in a manner that ensures viability of said cellular components. - View Dependent Claims (13)
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14. A method of treating a patient comprising:
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constructing a three dimensional scaffold to support cell growth, said three dimensional scaffold including a first layer for supporting cell growth, and a second layer for supporting cell growth, said first and second layers being mechanically connected to each other; and implanting said three dimensional scaffold in the patient. - View Dependent Claims (15, 16, 17, 18, 19)
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Specification