Method and device for measuring the intra-cranial pressure in the skull of a test subject

• US 6,146,336 A
• Filed: 01/19/1999
• Issued: 11/14/2000
• Est. Priority Date: 02/22/1996
• Status: Expired due to Fees

• Current Assignee: Nicolet Biomedical, Inc. (Thermo Fisher Scientific Incorporated)
• Original Assignee: Nicolet Biomedical, Inc. (Thermo Fisher Scientific Incorporated)
• Inventors: Paulat, Klaus
• Primary Examiner(s): Lacyk, John P.
• Assistant Examiner(s): MARMOR II, CHARLES ALAN
• Application Number:
  US09/125,652
• Time in Patent Office: 665 Days
• Field of Search: 600/547, 600/561, 600/587, 600/544, 73/717, 73/718, 73/719, 73/723, 73/724, 73/725
• US Class Current: 600/561
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/031 Intracranial pressure
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/4884 inducing physiological or psychological stress, e.g. applications for stress testing

Abstract

In order to detect the intra-cranial pressure in the skull of a test subject it is proposed to attach to the skull at least two electrodes in such a way that they have an electrical contact with the skull. Via a measuring device, the time curve of an electrical resistance and/or of a capacitance between the two electrodes is obtained as an electrical signal (p(t)). An extreme value of the electrical signal, following a blood pressure maximum according to a systole with a substantially uniform delay, is determined as a first amplitude value. A second amplitude value is obtained from the electrical signal (p(t)). This value is accepted at a point where the electrical signal has for the first time after the first amplitude value either a maximum or a turning point. A third amplitude value is obtained from the electrical signal after the second amplitude value. A standardized pressure measurement value is obtained from the amplitude values for further utilization. By means of this type of measurement it is possible to establish the intra-cranial pressure of a test subject in a simple, rapid and cost-effective manner, and to observe it even over lengthy periods, without thereby stressing the test subject.

Claims

1. Method of measuring an intra-cranial pressure (ICP) in the skull of a test subject, comprising the steps:

attaching two electrodes to the skull of the test subject in such a way that the electrodes have an electrical contact with the skull;

obtaining a time curve of an electrical parameter between the two electrodes as an electrical signal (p(t));

determining an extreme value of the electrical signal following a maximum in blood pressure corresponding to a systole with a substantially uniform delay as a first amplitude value (Pmin);

obtaining a second amplitude value (P1) from the electrical signal (p(t)), where this has for the first time after the first amplitude value (Pmin) either a maximum (.P(t)=0) or a turning point (..p(t)=0);

obtaining a third amplitude value (P2) from the electrical signal after the second amplitude value;

obtaining a standardized pressure measurement value from the amplitude values (Pmin, P1, P2) for further utilization.

2. Method of claim 1 wherein the electrical parameter comprises capacitance.

3. Method of claim 1 wherein the electrical parameter comprises resistance.

4. Method of claim 1 wherein the electrical parameter comprises resistance and capacitance.

5. Method according to claim 1, wherein a quotient (P2/P1) is formed from the second amplitude value (P1) and the third amplitude value (P2) in order to obtain the standardized pressure measurement value.

6. Method according to claim 1, wherein in order to form a vector a start point is formed for the vector at the second amplitude value (P1) and an end point for the vector at the third amplitude value (P2), and the standardized pressure measurement value is formed from the vector.

7. Method according to claim 1, wherein in order to form a vector a start point for the vector is formed at the first amplitude value (Pmin) and an end point for the vector is formed at the second amplitude value (P1) and the standardized pressure measurement value is formed from the vector.

8. Method according to claim 1, wherein a period of time is defined after the second amplitude value (P1), after which the third amplitude value (P2) is scanned from the electrical signal (p(t)).

9. Method according to claim 8, wherein the curve of the electrical signal (p(t)) is investigated over time and a fourth amplitude value (PI) is defined at a point where the curve of the electrical signal over time has an opposed curvature to the curve of the electrical signal over time at the second amplitude value (P1), and the defined span of time being derived from the time interval between the second amplitude value (P1) and the fourth amplitude value (PI).

10. Method according to claim 9, wherein the defined span of time comes to substantially half the time interval.

11. Method according to claim 1, wherein in order to form an average signal value, an average is taken from a plurality of electrical signals (p(t)).

12. Method according to claim 11, wherein the first amplitude value (Pmin) is used as a repeating start point in time for forming the average signal value.

13. Method according to claim 11, wherein at least one further electrode is attached to the test subject in order to obtain an ECG, and a value in the ECG is defined, which is used as a repeating start point in time for forming the average signal value.

14. Method according to claim 1, wherein in order to calibrate the measurement, at least one first and one second standardized pressure measurement value are obtained in at least one first and one second position of the test subject, the skull of the test subject in the first position being higher by a specific quantity relative to the spatial position of the heart of the test subject, particularly the right atrium of the heart, than in the second position.

15. Method according to claim 1, wherein the at least two electrodes are attached at positions on the skull of the test subject which lie as far apart as possible.

16. Method according to claim 15, wherein one electrode is attached in the region of the hairline of the forehead of the test subject, and one electrode in the area behind one ear of the test subject.

17. Method according to claim 1, wherein one of the at least two electrodes is connected to a ground electrode.

18. Method according to claim 17, wherein the ground electrode forms an electrode for simultaneous ECG derivation.

19. Device for measuring an intra-cranial pressure (ICP) in the skull of a test subject, comprising:

at least two electrodes which are attachable to the skull of the test subject in such a way that the electrodes have an electrical contact with the skull;

a measuring device for obtaining an electrical signal (p(t)) which represents a time curve of an electrical parameter between the at least two electrodes;

a storage device for storing the electrical signal (p(t));

a computer device for determining an extreme value of the electrical signal (p(t)), which follows a blood pressure maximum corresponding to a systole with a substantially uniform delay, and for determining a first amplitude value (Pmin) of the extreme value and to determine a second amplitude value (P1) from the electrical signal (p(t)) at the point where the electrical signal (p(t)) has for the first time after the first amplitude value (Pmin) either a maximum ((.p(t))=0) or a turning point ((..p(t))=0), and to determine a third amplitude value (P2) from the electrical signal (p(t)) after the second amplitude value (P1), and is used to obtain a standardized pressure measurement value from the amplitude values (Pmin, P1, P2); and

utilization devices selected from the group including a display device, a printer, and a writing station for writing out from data carriers.

20. Device of claim 19 wherein the electrical parameter comprises capacitance.

21. Device of claim 19 wherein the electrical parameter comprises resistance.

22. Device of claim 19 wherein the electrical parameter comprises resistance and capacitance.

23. Device according to claim 19, wherein the computer device is configured such that a quotient (P2/P1) is formed from the second amplitude value (P1) and the third amplitude value (P2), in order to obtain the standardized pressure measurement value.

24. Device according to claim 19, wherein the computer device is configured such that in order to form a vector, a start point is formed for the vector at the second amplitude value (P1) and an end point for the vector is formed at the third amplitude value (P2), and a standardized pressure measurement value is formed from the vector.

25. Device according to claim 19, wherein the computer device is configured such that, in order to from a vector, a start point for the vector is formed at the first amplitude value (Pmin) and an end point for the vector is formed at the second amplitude value (P1), and the standardized pressure measurement value is formed from the vector.

26. Device according to claim 19, comprising a time-determining device for determining time after the second amplitude value (P1), the computer device being configured such that the third amplitude value (P2) is scanned from the electrical signal after a predetermined span of time.

27. Device according to claim 26, wherein the computer device is configured such that the curve of the electrical signal (p(t)) over time is investigated, and a fourth amplitude value (PI) is defined at a point where the curve of the electrical signal over time has a curvature opposed to the curvature of the electrical signal over time at the second amplitude value (P1), and the computer device further being configured such that the defined span of time is derived from the time interval between the second amplitude value (P1) and the fourth amplitude value (PI).

28. Device according to claim 27, wherein the time-determining device is configured such that the defined time span comes to substantially half the time interval.

29. Device according to claim 19, wherein the measuring device, the storage device and the computer device are configured to form an average signal value from a plurality of electrical signals (p(t)).

30. Device according to claim 29, wherein the computer device is configured such that the first amplitude value (Pmin) can be obtained as a repeating start point in time for forming the average signal value.

31. Device according to claim 29, wherein a further electrode and a measuring device attached thereto are provided in order to obtain an ECG, the computer device being configured such that a value in ECG is defined which is used as a repeating start point in time for forming the average signal value.

32. Device according to claim 19, comprising a retaining device for supporting the test subject in at least two positions, the skull of the test subject in the first position lying by a specific amount higher relative to the spatial position of the right atrium of the heart of the test subject than in the second position, in such a way that in order to calibrate the measurement at least a first and a second standardized pressure measurement value can be obtained in the first and in the second positions.

33. Device according to claim 19, wherein the at least two electrodes are configured such that the electrodes are attachable at two positions of the skull of the test subject which lie as far apart as possible.

34. Device according to claim 33, wherein one electrode of the at least two electrodes is connected to a ground electrode.

35. Device according to claim 34, wherein the electrode connected to ground is applied to an ground input of a measuring device in order to obtain an ECG.