Catheter system and method for injection of a liquid embolic composition and a solidification agent
First Claim
1. A catheter for controlling solidification in vivo of liquid embolic compositions comprising:
- (a) a first tube formed of a DMSO compatible material, the first tube having a lumen;
(b) a second tube connected to the first tube, the second tube having a lumen, wherein the second tube coaxially surrounds the first tube;
(c) an actuator for sliding the first tube longitudinally with respect to the second tube;
(d) a first fluid delivery port connected to the lumen of the first tube for delivery of a liquid embolic composition which composition comprises a biocompatible, water-insoluble polymer dissolved in DMSO, the first delivery port formed of a DMSO compatible material;
(e) a second fluid delivery port connected to the lumen of the second tube for delivery of a solidification agent which encourages solidification of the liquid embolic composition; and
an anti-kinking mechanism for preventing kinking of the first tube as it slides in the second tube, the anti-kinking mechanism including a rigid tube connected to the first tube and a sleeve, wherein the rigid tube is slidable within the sleeve.
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Accused Products
Abstract
A catheter according to the present invention includes a multiple lumen catheter for delivery of a liquid embolic composition through a first lumen and delivery of a solidification agent through a second lumen. The catheter allows adjustment of the relative longitudinal position of the two lumens to control the solidification of the embolic composition within a blood vessel. The multiple lumen catheter system is used by inserting the catheter endovascularly into an aneurysm site and injecting a liquid embolic composition through the first lumen while injecting a solidification agent through the second lumen to wash the area of the aneurysm of blood which has become saturated with solvent, while replacing it with a fresh solidification agent. The controlled solidification of the liquid embolic composition by use of the solidification agent allows the aneurysm to be filled precisely and rapidly even when the aneurysm is located such that gravity does not cause the liquid embolic composition to flow into the aneurysm.
354 Citations
11 Claims
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1. A catheter for controlling solidification in vivo of liquid embolic compositions comprising:
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(a) a first tube formed of a DMSO compatible material, the first tube having a lumen; (b) a second tube connected to the first tube, the second tube having a lumen, wherein the second tube coaxially surrounds the first tube; (c) an actuator for sliding the first tube longitudinally with respect to the second tube; (d) a first fluid delivery port connected to the lumen of the first tube for delivery of a liquid embolic composition which composition comprises a biocompatible, water-insoluble polymer dissolved in DMSO, the first delivery port formed of a DMSO compatible material; (e) a second fluid delivery port connected to the lumen of the second tube for delivery of a solidification agent which encourages solidification of the liquid embolic composition; and an anti-kinking mechanism for preventing kinking of the first tube as it slides in the second tube, the anti-kinking mechanism including a rigid tube connected to the first tube and a sleeve, wherein the rigid tube is slidable within the sleeve. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A catheter for controlling solidification in vivo of liquid embolic compositions comprising:
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(a) a first tube formed of a DMSO compatible material, the first tube having a lumen; (b) a second tube connected to the first tube, the second tube having a lumen; (c) an actuator for sliding the first tube longitudinally with respect to the second tube; (d) a first fluid delivery port connected to the lumen of the first tube for delivery of a liquid embolic composition which composition comprises a biocompatible, water-insoluble polymer dissolved in DMSO, the first delivery port formed of a DMSO compatible material; (e) a second fluid delivery port connected to the lumen of the second tube for delivery of a solidification agent which encourages solidification of the liquid embolic composition; and wherein a joint is provided between the distal and proximal portions of the first tube and the joint is longitudinally displaced from a joint which is provided between the distal and proximal portions of the second tube at all relative positions of the catheter which are achieved by manipulation of the actuator. - View Dependent Claims (8, 9, 10, 11)
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Specification