Percutaneous absorption preparation

• US 6,146,656 A
• Filed: 01/19/1999
• Issued: 11/14/2000
• Est. Priority Date: 01/22/1998
• Status: Expired due to Fees

• Current Assignee: Nitto Denko Corporation
• Original Assignee: Nitto Denko Corporation
• Inventors: Nakano, Yoshihisa, Minomi, Kenjiro, Hori, Mitsuhiko
• Primary Examiner(s): Jarvis, William R. A.
• Assistant Examiner(s): KIM, VICKIE Y
• Application Number:
  US09/232,684
• Time in Patent Office: 665 Days
• Field of Search: 424/448, 424/449, 424/484, 514/772, 514/319, 528/364, 524/394
• US Class Current: 424/448
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61K 9/7061 Polyacrylates

Abstract

The present invention provides a percutaneous absorption preparation which comprises a skin contact base containing therein at least one active ingredient selected from the group consisting of biperiden, trihexyphenidyl and pharmacologically acceptable salts thereof in an amount of from 0.5 to 60% by weight. The percutaneous absorption preparation makes it possible to permit the percutaneous absorption of biperiden, trihexyphenidyl or pharmacologically acceptable salt thereof as an active ingredient so that the medicament can be used effectively and at the same time, pharmacological effects can be sustained long and administration can be carried out conveniently. In addition, the active ingredient contained in it can be maintained stably.

Claims

1. A percutaneous absorption preparation which comprises a skin contact base containing biperiden-HCl in an amount of from 0.5 to 60% by weight, a freeing agent, and wherein the skin contact base is pressure sensitive adhesive having adhesion at room temperature and a layer made of said pressure-sensitive adhesive is formed on one side of a backing material, wherein said pressure sensitive adhesive is at least one of an acrylic pressure sensitive adhesive and a rubber pressure sensitive adhesive.

2. The percutaneous absorption preparation of claim 1, wherein said pressure-sensitive adhesive is an acrylic pressure-sensitive adhesive comprising alkyl acrylate or alkyl methacrylate.

3. The percutaneous absorption preparation of claim 1, wherein said skin contact base contains at least one organic liquid ingredient selected from the group consisting of glycols, oils and fats, fatty acids, alcohols and fatty acid esters.

4. The percutaneous absorption preparation of claim 3, wherein said skin contact base contains the at least one organic liquid ingredient in an amount of 2 to 50% by weight.

5. The percutaneous absorption preparation of claim 1 wherein the skin contact base contains biperiden-HCl in an amount of from 1% to 30% by weight.

6. The percutaneous absorption preparation of claim 1, wherein the freeing agent is selected from the group consisting of sodium hydroxide, potassium hydroxide, tetraethylamine, tetraethylammonium, amonia, and sodium caprylate.

7. The percutaneous absorption preparation of claim 6 wherein the freeing agent is sodium hydroxide.

8. The percutaneous absorption preparation of claim 7 wherein the sodium hydroxide is present in a ratio of 1.5 parts per 10 parts biperiden HCl.