Method and apparatus for measuring concentration by light projection

• US 6,147,749 A
• Filed: 04/29/1997
• Issued: 11/14/2000
• Est. Priority Date: 08/07/1995
• Status: Expired due to Term

• Current Assignee: Kurashiki Boseki Kabushi Kaisha, Kurashiki Boseki Kabushiki Kaisha, Kyoto Daiichi Kagaku Company Limited
• Original Assignee: Kurashiki Boseki Kabushiki Kaisha, Kyoto Daiichi Kagaku Company Limited
• Inventors: Mitsumura, Yoshio, Xu, Kexin, Kubo, Hiroko, Uenoyama, Harumi
• Primary Examiner(s): Font, Frank G.
• Assistant Examiner(s): Smith, Zandra V.
• Application Number:
  US08/817,085
• Time in Patent Office: 1,295 Days
• Field of Search: 356/39, 356/436, 600/310, 600/314, 378/205
• US Class Current: 356/39
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/6825 Hand
• CPC Class Codes: A61B 5/6842 by marking the skin
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure
• CPC Class Codes: G01N 21/27 using photo-electric detection G01N21/31 takes precedence; circuits for computing concentration logarithmic circuits G06G7/24; photometric circuits in general G01J

Abstract

To project measuring light with good reproducibility onto the measuring part of a measured object so that measurement conditions can always be constant. An optical measuring apparatus is equipped with a spectroscopic analyzer that detects the spectral intensity of the reflected light of measuring light projected onto a human hand. Spectroscopic analyzer moves in the direction" of the X-axis, Y axis, and Z axis, and around the Z axis by a moving mechanism. During the registration of the measuring part of the human hand, a CCD camera takes a picture of the human hand, and the operator selects a part having a feature from the pattern of the taken image. During the spectrometry, the CCD camera again takes a picture of the human hand. The optical measuring apparatus then detects the registered feature part on the currently taken image, moves spectroscopic analyzer by moving mechanism, and projects measuring light onto the registered feature part.

Claims

1. A measuring apparatus that has a projection optical system, projects measuring light onto a measured object, and detects a spectral intensity of the light transmitted or reflected by the measured object to measure a concentration of a particular component within the measured object based on the spectral intensity;

said measuring apparatus comprising;

measured-object mounting means for mounting the measured object,

image pickup means for taking a picture of the measured object,

image display means for displaying an image of the measured object,

image registration means, during registration of a measuring location, for storing as a registered image an image in which a part having a visually recognized feature is marked by selecting the part from a pattern of the image of the measured object displayed on said image display means, and

moving means, during the restoration of the measuring location, for comparing the pattern of said registered image with a pattern of a currently taken image of the measured object to move said projection optical system so that the measuring light is projected onto a location of a part corresponding to the marked part of the registered image, in the currently taken image of the measured object;

wherein the measurement is always performed by projecting the measuring light onto an identical part of the measured object;

wherein said projection optical system moves in directions of an X axis and a Y axis that are orthogonal to a Z axis that is oriented in a direction of an optical axis of the measuring light.

2. The measuring apparatus of claim 1 wherein said image registration means stores as the registered image the marked image together with information that identifies the measured object.

3. The measuring apparatus of claim 1, wherein said projection optical system moves in the direction of the Z axis.

4. The measuring apparatus of claim 1, wherein said projection optical system rotates around the Z axis.

5. The measuring apparatus of claim 1, wherein said measuring apparatus further comprises a contact pressure sensor that detects contact pressure between the measured object and said measured object mounting means, a contact pressure memory that stores an output of said contact pressure sensor, and a pressurization device that reproduces the contact pressure stored in said contact pressure memory.

6. A measuring apparatus that has a projection optical system, projects measuring light onto a measured object, and detects a spectral intensity of the light transmitted or reflected by the measured object to measure a concentration of a particular component within the measured object based on the spectral intensity;

said measuring apparatus comprising;

measured-object mounting means for mounting the measured object,

image pickup means for taking a picture of the measured object,

image display means for displaying an image of the measured object,

image registration means, during registration of a measuring location, for storing as a registered image an image in which a part having a visually recognized feature is marked by selecting the part from a pattern of the image of the measured object displayed on said image display means, and

moving means, during the restoration of the measuring location, for comparing the pattern of said registered image with a pattern of a currently taken image of the measured object to move said projection optical system so that the measuring light is projected onto a location of a part corresponding to the marked part of the registered image, in the currently taken image of the measured object;

wherein the measurement is always performed by projecting the measuring light onto an identical part of the measured object;

wherein said projection optical system moves in the direction of the Z axis.

7. A measuring apparatus that has a projection optical system, projects measuring light onto a measured object, and detects a spectral intensity of the light transmitted or reflected by the measured object to measure a concentration of a particular component within the measured object based on the spectral intensity;

said measuring apparatus comprising;

measured-object mounting means for mounting the measured object,

image pickup means for taking a picture of the measured object,

image display means for displaying an image of the measured object,

image registration means, during registration of a measuring location, for storing as a registered image an image in which a part having a visually recognized feature is marked by selecting the part from a pattern of the image of the measured object displayed on said image display means, and

moving means, during the restoration of the measuring location, for comparing the pattern of said registered image with a pattern of a currently taken image of the measured object to move said projection optical system so that the measuring light is projected onto a location of a part corresponding to the marked part of the registered image, in the currently taken image of the measured object;

wherein the measurement is always performed by projecting the measuring light onto an identical part of the measured object;

wherein said projection optical system rotates around the Z axis.

8. A measuring apparatus that has a projection optical system, projects measuring light onto a measured object, and detects a spectral intensity of the light transmitted or reflected by the measured object to measure a concentration of a particular component within the measured object based on the spectral intensity;

said measuring apparatus comprising;

measured-object mounting means for mounting the measured object,

image pickup means for taking a picture of the measured object,

image display means for displaying an image of the measured object,

image registration means, during registration of a measuring location, for storing as a registered image an image in which a part having a visually recognized feature is marked by selecting the part from a pattern of the image of the measured object displayed on said image display means, and

moving means, during the restoration of the measuring location, for comparing the pattern of said registered image with a pattern of a currently taken image of the measured object to move said protection optical system so that the measuring light is projected onto a location of a part corresponding to the marked part of the registered image, in the currently taken image of the measured object;

wherein the measurement is always performed by projecting the measuring light onto an identical part of the measured object;

wherein said measuring apparatus further comprises a contact pressure sensor that detects contact pressure between the measured object and said measured object mounting means, a contact pressure memory that stores an output of said contact pressure sensor, and a pressurization device that reproduces the contact pressure stored in said contact pressure memory.

9. A measuring apparatus that has a projection optical system, projects measuring light onto a measured object, and detects a spectral intensity of light transmitted or reflected by the measured object to measure a concentration of a particular component within the measured object based on the spectral intensity;

said measuring apparatus comprising;

measured-object mounting means for mounting the measured object,

image pickup means for taking a picture of the measured object,

image display means for displaying the image of the measured object,

image registration means, during the registration of the measuring location, for storing as a registered images an image in which a part having a visually recognized feature is marked by selecting the part from a pattern of the image of the measured object displayed on said image display means,

measuring location identifying means during the restoration of said measuring location, for comparing the pattern of the registered image with a pattern of the currently taken image of the measured object, identifies a location of the part corresponding to the marked part of the registered image, in the currently taken image of the measured object,

moving means for moving said projection optical system so that the measuring light is projected onto the part identified by said measuring location identifying means,

light receiving optical means for receiving the light transmitted or reflected by the measuring part,

spectral intensity detecting means for detecting the spectral intensity of the light transmitted or reflected by the measured object and received by said light receiving optical system,

arithmetic processing means for computing the concentration of a particular component within the measured object based on the spectral intensity, and

output means for outputting the concentration of the particular component.

10. The measuring apparatus of claim 9, wherein said projection optical system has an optical fiber.

11. The measuring apparatus of claims 9 or 10, wherein said light receiving optical system has an optical fiber.

12. The measuring apparatus of claims 9 or 10, wherein said light receiving optical system has an integrating sphere.

14. The measuring apparatus defined in claim 9, wherein said measured object is an organism.

13. The measuring apparatus of claim 13, wherein said image registration means stores the marked image as a registered image together with information that identifies the measured object.