Method of making a capillary for electrokinetic transport of materials

• US 6,148,508 A
• Filed: 03/12/1999
• Issued: 11/21/2000
• Est. Priority Date: 03/12/1999
• Status: Expired due to Fees

• Current Assignee: Caliper Holdings Incorporated
• Original Assignee: Caliper Holdings Incorporated
• Inventors: Wolk, Jeffrey A.
• Primary Examiner(s): Arbes, Carl J.
• Application Number:
  US09/267,428
• Time in Patent Office: 620 Days
• Field of Search: 29/411, 29/412, 29/33 D, 29/417, 29/825, 204/451, 204/604, 205/118, 205/122, 205/163
• US Class Current: 29/825
• CPC Class Codes: B01F 33/3031 using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
• CPC Class Codes: B01F 33/3032 using magneto-hydrodynamic [MHD] phenomena to mix or move the fluids
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/0838 Capillaries
• CPC Class Codes: B01L 2300/16 Surface properties and coatings
• CPC Class Codes: B01L 2400/0415 electrical forces, e.g. electrokinetic
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: G01N 27/44704 Details; Accessories
• CPC Class Codes: Y10S 366/02 Micromixers: segmented laminar flow with boundary mixing orthogonal to the direction of fluid propagation with or without geometry influences from the pathway
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing
• CPC Class Codes: Y10T 29/49787 Obtaining plural composite product pieces from preassembled workpieces
• CPC Class Codes: Y10T 29/49798 Dividing sequentially from leading end, e.g., by cutting or breaking

Abstract

A method for fabricating a capillary element for electrokinetic transport of materials. The method comprises providing a first capillary element which has a first capillary channel disposed through its length. The capillary channel comprises first and second ends and an outer surface. A continuous layer of an electrically conductive material is applied along a length of the outer surface such that the continuous layer of electrically conductive material extends along the outer surface to a point proximal to, but not up to at least one of the first and second ends. The capillary element is then segmented into at least first and second separate capillary element portions at an intermediate point of the capillary element and the continuous layer.

Claims

1. A method for fabricating a capillary element for electrokinetic transport of materials, comprising:

providing a first capillary element having disposed through its length, a first capillary channel, the capillary channel comprising first and second ends and an outer surface;

applying a continuous layer of an electrically conductive material along a length of the outer surface, the continuous layer of electrically conductive material extending along the outer surface to a point proximal to, but not up to at least one of the first and second ends;

segmenting the capillary element into at least first and second separate capillary element portions at an intermediate point of the capillary element and the continuous layer, the first portion comprising the first end and a first intermediate end, and the second portion comprising the second end and a second intermediate end.

2. The method of claim 1, wherein the applying step comprises applying a conductive metal layer to the capillary element.

3. The method of claim 2, wherein the conductive metal layer is sputtered onto the outer surface of the capillary element.

4. The method of claim 2, wherein the conductive metal layer comprises a metal selected from platinum, chrome, titanium, tungsten, and rhodium.

5. The method of claim 1, wherein the conductive layer comprises a metallic paint that is painted onto the outer surface of the capillary element.

6. The method of claim 1, wherein the segmenting step comprises sawing the capillary element into the first and second portions at the intermediate point.

7. The method of claim 1, further comprising the step of attaching at least one of the first and second ends of the first and second portions of the capillary element to a substrate having at least a first channel disposed in an interior portion thereof, such that the capillary channel extending the length of the first or second capillary portion is in fluid communication with the at least first channel disposed in the substrate.

8. The method of claim 7, wherein the attaching step comprises providing the substrate with a cavity disposed therein, the cavity being dimensioned for receiving the first or second end of the capillary element.

9. The method of claim 8, wherein the cavity is fabricated by drilling a hole into at least one surface of the substrate, the hole providing fluid communication with the first channel in the interior portion of the substrate.

10. The method of claim 8 wherein the cavity comprises an etched opening in at least one surface of the substrate, the etched opening providing fluid communication with the first channel in the interior portion of the substrate.

11. The method of claim 8, wherein the capillary element provided in the providing step comprises a rectangular cross-sectional shape, and the cavity comprises a rectangular shape dimensioned to receive the capillary element.

12. The method of claim 1, further comprising attaching an electrical lead to the continuous layer of the first or second portion.

13. The method of claim 1, wherein the continuous layer is applied to a point that is greater than 0.1 mm from at least one of the first and second ends.

14. The method of claim 1, wherein the continuous layer is applied to a point that is greater than 0.2 mm from at least one of the first and second ends.

15. The method of claim 1, wherein the continuous layer is applied to a point that is greater than 0.5 mm from at least one of the first and second ends.

16. The method of claim 1, wherein the continuous layer is applied to a point that is greater than 1 mm from at least one of the first and second ends.

17. The method of claim 1, wherein the continuous layer is applied to a point that is greater than 2 mm from at least one of the first and second ends.