On-line and real-time spectroreflectometry measurement of oxygenation in a patient's eye

• US 6,149,589 A
• Filed: 03/22/1999
• Issued: 11/21/2000
• Est. Priority Date: 03/26/1998
• Status: Expired due to Fees

• Current Assignee: Universite De Montreal, L'
• Original Assignee: Universite De Montreal, L'
• Inventors: Faubert, Jocelyn, Diaconu, Vasile
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/273,857
• Time in Patent Office: 610 Days
• Field of Search: 600/318, 600/320, 600/322, 600/323, 600/340, 600/473, 600/476, 606/2, 606/3, 606/4, 606/5, 606/6, 606/10, 606/11, 606/13, 606/17, 606/18
• US Class Current: 600/318
• CPC Class Codes: A61B 3/1241 specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
• CPC Class Codes: A61B 5/14555 specially adapted for the eye fundus

Abstract

In the spectroreflectometry oxygenation measuring method and device, a light source produces a light beam having a spectral bandwidth including the wavelengths from 450 nm to 850 nm. A first optical system propagates the light beam from the light source to a two-dimensional area of the fundus of a patient'"'"'s eye, the light beam being reflected at least in part by the fundus of the patient'"'"'s eye to produce a reflected light beam. A detector unit detects the spectral content of the reflected light beam and produces a signal indicative of the spectral content of this reflected light beam. A second optical system propagates the reflected light beam from the fundus of the patient'"'"'s eye to the detector unit. This second optical system comprises an optical scanning sub-system for scanning a plurality of points of the two-dimensional area of the fundus of the patient'"'"'s eye. Finally, the optical scanning sub-system comprises optical elements for transmitting to the detector unit only a portion of the reflected light beam corresponding to the point of the two-dimensional area being scanned to thereby conduct at this point a spectroreflectometry oxygenation measurement.

Claims

1. A spectroreflectometry oxygenation measuring device, comprising:

a light source for producing a light beam having a predetermined spectral bandwidth;

a first optical system for propagating the light beam from the light source to a two-dimensional area of the fundus of a patient'"'"'s eye, the light beam being reflected at least in part by the fundus of the patient'"'"'s eye to produce a reflected light beam;

a detector unit for detecting the spectral content of the reflected light beam and for producing a signal indicative of the spectral content of said reflected light beam; and

a second optical system for propagating the reflected light beam from the fundus of the patient'"'"'s eye to the detector unit, wherein said second optical system comprises;

an optical scanning sub-system for scanning a plurality of points of the two-dimensional area of the fundus of the patient'"'"'s eye, said optical scanning sub-system comprising;

optical elements for transmitting to the detector unit only a portion of the reflected light beam corresponding to the point of said two-dimensional area being scanned to thereby conduct at said point a spectroreflectometry oxygenation measurement.

2. The spectroreflectometry oxygenation measuring device as recited in claim 1, wherein the predetermined spectral bandwidth includes a range of wavelengths comprised between 450 nm and 850 nm.

3. The spectroreflectometry oxygenation measuring device as recited in claim 1, wherein the detector unit comprises:

a spectrograph responsive to said portion of the reflected light beam to produce a light spectrum including light components of said portion of the reflected light beam arranged in order of wavelengths; and

an array of detectors for measuring intensities of the light components of different wavelengths of the light spectrum.

4. The spectroreflectometry oxygenation measuring device as recited in claim 1, wherein the light beam produced by the light source has an intensity sufficiently low for being applied to the fundus of the patient'"'"'s eye for the duration of the spectroreflectometry oxygenation measurement while causing no harm to the patient'"'"'s eye.

5. The spectroreflectometry oxygenation measuring device as recited in claim 1, wherein said optical elements comprise:

a first mirror rotating about a first axis and comprising at least one peripheral light-reflecting facet for deviating the reflected light beam as the first mirror rotates about the first axis; and

a second mirror rotating about a second axis and comprising at least one peripheral light-reflecting facet for deviating the reflected light beam from the first mirror toward the detector unit.

6. The spectroreflectometry oxygenation measuring device as recited in claim 5, wherein the first and second axes are perpendicular to each other, and wherein the first axis is perpendicular to the reflected light beam from the fundus of the patient'"'"'s eye.

7. The spectroreflectometry oxygenation measuring device as recited in claim 5, wherein said optical elements further comprise a mirror situated between the second mirror and the detector unit, this mirror being formed with an opening for transmitting to the detector unit the above mentioned portion of the reflected light beam corresponding to the point being scanned.

8. The spectroreflectometry oxygenation measuring device as recited in claim 1, wherein the scanned points are slit-shaped points, and wherein said optical elements comprise:

a first mirror rotating about a rotation axis and comprising at least one peripheral light-reflecting facet for deviating the reflected light beam as the first mirror rotates about the rotation axis; and

a second mirror formed with a slit opening for transmitting to the detector unit the portion of the reflected light beam corresponding to the slit-shaped point of the two-dimensional area being scanned.

9. A spectroreflectometry oxygenation measuring method comprising the steps of:

producing a light beam having a predetermined spectral bandwidth by means of a light source;

propagating the light beam from the light source to a two-dimensional area of the fundus of a patient'"'"'s eye;

reflecting at least in part the light beam on the fundus of the patient'"'"'s eye to produce a reflected light beam;

by means of a detector unit, detecting the spectral content of the reflected light beam and producing a signal indicative of the spectral content of said reflected light beam; and

propagating the reflected light beam from the fundus of the patient'"'"'s eye to the detector unit, wherein said reflected light beam propagating step comprises the substep of;

scanning a plurality of points of the two-dimensional area of the fundus of the patient'"'"'s eye, said scanning substep comprising the substep of;

transmitting to the detector unit only a portion of the reflected light beam corresponding to the point of said two-dimensional area being scanned to thereby conduct at said point a spectroreflectometry oxygenation measurement.

10. The spectroreflectometry oxygenation measuring method as recited in claim 9, wherein said light beam producing step comprises producing a light beam having a spectral bandwidth including a range of wavelengths comprised between 450 nm and 850 nm.

11. The spectroreflectometry oxygenation measuring method as recited in claim 9, wherein the light beam producing step comprises producing a light beam having an intensity sufficiently low for being applied to the fundus of the patient'"'"'s eye for the duration of the spectroreflectometry oxygenation measurement while causing no harm to the patient'"'"'s eye.

12. The spectroreflectometry oxygenation measuring method as recited in claim 9, wherein said scanning substep comprises:

rotating about a first axis a first mirror comprising at least one light-reflecting facet for deviating the reflected light beam as said first mirror rotates about the first axis; and

rotating about a second axis a second mirror comprising at least one light-reflecting facet for deviating the reflected light beam from the first mirror toward the detector unit.

13. The spectroreflectometry oxygenation measuring method as recited in claim 12, wherein said transmitting substep comprises transmitting to the detector unit said portion of the reflected light beam corresponding to the point of said two-dimensional area being scanned through an opening of a third mirror situated between the second mirror and the detector unit.

14. The spectroreflectometry oxygenation measuring method as recited in claim 9, wherein:

the scanned points are slit-shaped points;

the scanning substep comprises rotating about a rotation axis a first mirror comprising at least one light-reflecting facet for deviating the reflected light beam as said first mirror rotates about said rotation axis; and

the transmitting substep comprises transmitting to the detector unit and through a slit opening of a second mirror said portion of the reflected light beam corresponding to the slit-shaped point of said two-dimensional area being scanned.