Methods and devices for the preparation, storage and administration of calcium phosphate cements

• US 6,149,655 A
• Filed: 12/12/1997
• Issued: 11/21/2000
• Est. Priority Date: 12/13/1996
• Status: Expired due to Term

• Current Assignee: Norian Corporation (Johnson & Johnson)
• Original Assignee: Norian Corporation (Johnson & Johnson)
• Inventors: Constantz, Brent R., Clawson, Ben
• Primary Examiner(s): Buiz, Michael
• Assistant Examiner(s): HO, TAN-UYEN THI
• Application Number:
  US08/989,845
• Time in Patent Office: 1,075 Days
• Field of Search: 606/90, 606/91, 606/92, 606/93, 606/94, 606/95, 222/145.1, 604/87, 604/89, 604/416, 206/219
• US Class Current: 606/94
• CPC Class Codes: A61B 17/8822 characterised by means facilitating expulsion of fluid from the introducer, e.g. a screw pump plunger, hydraulic force transmissions, application of vibrations or a vacuum
• CPC Class Codes: A61B 17/8827 with filtering, degassing, venting or pressure relief means
• CPC Class Codes: A61B 17/8833 Osteosynthesis tools specially adapted for handling bone cement or fluid fillers; Means for supplying bone cement or fluid fillers to introducing tools, e.g. cartridge handling means
• CPC Class Codes: A61B 2017/8838 for mixing bone cement or fluid fillers
• CPC Class Codes: A61B 2090/037 with a frangible part, e.g. by reduced diameter
• CPC Class Codes: A61J 1/2027 having frangible parts
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: B01F 31/55 the materials to be mixed being contained in a flexible bag submitted to periodical deformation
• CPC Class Codes: B01F 33/5011 portable during use, e.g. hand-held
• CPC Class Codes: B01F 35/713 comprising breaking packages or parts thereof, e.g. piercing or opening sealing elements between compartments or cartridges containers or packages per se B65D
• CPC Class Codes: B01F 35/7131 Breaking or perforating packages, containers or vials
• CPC Class Codes: B01F 35/7162 A container being placed inside the other before contacting the contents
• CPC Class Codes: B05C 17/00553 with means allowing the stock of material to consist of at least two different components
• CPC Class Codes: B05C 17/01 with manually mechanically or electrically actuated piston or the like B05C17/00533 takes precedence
• CPC Class Codes: B65D 81/3266 separated by a common rupturable seal, a clip or other removable fastening device
• CPC Class Codes: B65D 81/3272 formed by arranging one flexible container within another

Abstract

A system is provided for the storage, preparation and administration of calcium phosphate cements. The subject invention provides a storage means for storing a two component calcium phosphate cement having a liquid component and a dry component. Also provided is a preparation means for combining the two components of the cement while present in the storage means. The subject invention further provides a means for administering the prepared cement to a physiological site. The subject devices and methods find use in a variety of applications where the introduction of a flowable material capable of setting to a solid calcium phosphate mineral to a physiological site is desired, including dental and orthopedic applications.

Claims

1. A storage means for a two component calcium phosphate cement, said storage means comprising:

a first compartment for housing a liquid component of said two component cement;

a second compartment for housing a dry component of said two component cement, said second compartment comprising a means for selectively allowing the passage of gas out of said compartment;

a first frangible barrier separating said first and second compartments;

a third elongated compartment for receiving the product produced by combining the contents of said first and second compartments; and

a second frangible barrier separating said third compartment from said second compartment.

2. The storage means according to claim 1, wherein said third elongate compartment further comprises a fitment means distal from said second frangible barrier.

3. The storage means according to claim 1, wherein at least said second compartment comprises rounded corners.

4. The storage means according to claim 1, wherein said storage means further comprises a two component calcium phosphate cement.

5. A storage means comprising a two component calcium phosphate cement consisting of a dry component and a liquid component, said storage means comprising:

a first compartment comprising said liquid component;

a second compartment having rounded comers and comprising said dry component;

a first frangible barrier separating said first and second compartments;

a third elongate compartment capable of receiving a product produced upon combination of said dry and liquid components; and

a second frangible barrier separating said second and third compartments.

6. The storage means according to claim 5, wherein said liquid component is a salt solution.

7. The storage means according to claim 5, wherein said dry component comprises a calcium source, a partially neutralized phosphoric acid and a carbonate source.

8. The storage means according to claim 5, wherein said second compartment further comprises a means for selectively allowing the passage of gas out of said compartment.

9. The storage means according to claim 5, wherein said third compartment further comprises a fitment means distal from said second frangible barrier.

10. The storage means according to claim 5, wherein said storage means further comprises an at least partially removable containment means surrounding said first, second and third compartments.

11. A kit for preparing a flowable material capable of setting into a calcium phosphate mineral, said kit comprising:

a storage means according to claim 5.

12. The kit according to claim 11, wherein said kit further comprises at least one tubular delivery means.