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BMP products

  • US 6,150,328 A
  • Filed: 06/14/1991
  • Issued: 11/21/2000
  • Est. Priority Date: 07/01/1986
  • Status: Expired due to Term
First Claim
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1. A method for induction selected from the group consisting of the induction of bone formation, cartilage formation and the formation of the combination thereof in a patient comprising administering an amount of a purified BMP-2 protein effective for inducing said formation of bone, cartilage and the combination thereof said BMP-2 protein produced by the steps of:

  • (a) culturing under suitable conditions a cell transformed with a DNA sequence selected from the group consisting of(i) a cDNA comprising the nucleotide sequence from nucleotide #356 to #1543 of SEQ ID NO;

    3 encoding a subunit of BMP-2; and

    (ii) DNA sequences comprising a nucleotide sequence which encodes a subunit having the 98 amino acid sequence from amino acid #17 to amino acid #114 of SEQ ID NO;

    4said DNA sequence in operative association with an expression control sequence therefor(b) recovering and purifying from said culture medium a protein wherein each subunit comprises the 98 amino acid sequence from amino acid #17 to amino acid #114 of SEQ ID NO;

    4 said protein having induction activity selected from the group consisting of bone, cartilage and the combination thereof.

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