Solid foamed active substance preparations

• US 6,150,424 A
• Filed: 03/01/1999
• Issued: 11/21/2000
• Est. Priority Date: 09/03/1996
• Status: Expired due to Term

• Current Assignee: Abbvie Deutschland GmbH & Company KG (Abbvie Incorporated)
• Original Assignee: BASF AG (BASF SE)
• Inventors: Breitenbach, Jorg, Baumgartl, Horst
• Primary Examiner(s): Clardy, S. Mark
• Assistant Examiner(s): George, Konata M.
• Application Number:
  US09/254,012
• Time in Patent Office: 631 Days
• Field of Search: 424/465, 514/772.4
• US Class Current: 514/772.5
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/277 having a ring, e.g. verapamil
• CPC Class Codes: A61K 31/401 Proline; Derivatives thereof, e.g. captopril
• CPC Class Codes: A61K 31/4422 1,4-Dihydropyridines, e.g. nifedipine, nicardipine
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 31/616 by carboxylic acids, e.g. acetylsalicylic acid
• CPC Class Codes: A61K 9/122 Foams; Dry foams edible foams A61K9/0056
• CPC Class Codes: A61K 9/2095 Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing mechanical aspects A61J3/00
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: C08J 2339/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C08J 9/122 Hydrogen, oxygen, CO2, nitrogen or noble gases

Abstract

Solid foamed active ingredient preparations based on melt-processable polymers, obtainable by extrusion of a melt of one or more polymers which comprises active ingredient and which is impregnated with a volatile, physiologically acceptable blowing agent and expanded.

Claims

1. A solid, shaped and partially or completely foamed active ingredient form comprising at least one thermoplastic polymer.

2. An active ingredient form as claimed in claim 1, comprising as thermoplastic polymer a homo- or copolymer of N-vinylpyrrolidone.

3. An active ingredient form as claimed in claim 1, comprising an active ingredient selected from ibuprofen, ketoprofen, flurbiprofen, acetylsalicylic acid, verapamil, paracetamol, nifedipine, caffeine, captopril and vitamins or mixtures of two or more of these active ingredients.

4. A process for producing active ingredient forms as claimed in claim 1, which comprises extruding a melt comprising, besides one or more active ingredients, at least one thermoplastic polymer and a volatile, physiologically acceptable blowing agent, and shaping the expanded extrudate to the required active ingredient form.

5. A process for producing active ingredient forms as claimed in claim 1, which comprises coextruding at least two melts, each of which comprises a thermoplastic polymer and at least one of which comprises one or more active ingredients and at least one of which comprises a physiologically acceptable blowing agent, and shaping the expanded extrudate to the required active ingredient forms.

6. A process for producing active ingredient forms as claimed in claim 1, which comprises extruding a melt which, besides one or more active ingredients, comprises at least one thermoplastic binder, subjecting the still plastic melt to a shaping, impregnating the solid active ingredient form under pressure with a volatile, physiologically acceptable blowing agent, and subsequently expanding.

7. An active ingredient form obtained by the process as claimed in claim 4.

8. An active ingredient form obtained by the process as claimed in claim 5.

9. An active ingredient form obtained by the process as claimed in claim 6.